益瘘搽剂治疗血液透析患者动静脉内瘘狭窄的效果观察  

Efficacy of Yilou liniment in the treatment of hemodialysis patients with arteriovenous fistula stenosis

作　　者：徐昇 陈志裕 XU Sheng;CHEN Zhiyu(Department of Nephrology Internal Medicine,Quzhou Hospital of Traditional Chinese Medicine,Quzhou,Zhejiang 324002,China)

机构地区：[1]衢州市中医医院肾内科,浙江衢州324002

出　　处：《医药前沿》2025年第13期17-20,共4页Journal of Frontiers of Medicine

基　　金：浙江中医药大学附属医院科研专项(2022FSYYZY42);衢州市指导性科技攻关项目(2021082)。

摘　　要：目的探讨益瘘搽剂治疗血液透析患者动静脉内瘘狭窄的临床效果。方法选取2022年1月—2024年4月衢州市中医医院收治的80例动静脉内瘘狭窄的血液透析患者,采用随机数字表法分为观察组和对照组,每组40例。对照组患者接受内科基础治疗,透析完成24 h后,对内瘘不作任何处理;观察组在对照组内科基础治疗基础上给予益瘘搽剂沿血管均匀涂擦。连续治疗24周后比较两组临床疗效、内瘘血流量、穿刺点近心端内径、穿刺点远心端内径、尿素清除分数(KT/V)、尿素下降率(URR)、白细胞介素-6(IL-6)和转化生长因子-β(TGF-β)水平。结果观察组治疗总有效率高于对照组;治疗后,观察组内瘘血流量、穿刺点远心端内径增大,且大于对照组,差异有统计学意义(P<0.05)。治疗后,观察组URR升高,IL-6和TGF-β降低,且观察组URR高于对照组,IL-6和TGF-β低于对照组,差异有统计学意义(P<0.05)。观察组并发症总发生率低于对照组,差异有统计学意义(P<0.05)。结论益瘘搽剂治疗血液透析患者动静脉内瘘狭窄效果显著,可增加内瘘血流量,增大血管穿刺点远心端内径,减少并发症,同时增加URR,降低TGF-β和IL-6水平。Objective To explore the clinical efficacy of Yilou liniment in the treatment of hemodialysis patients with arteriovenous fistula stenosis.Methods A total of 80 hemodialysis patients with arteriovenous fistula stenosis admitted to Quzhou Hospital of Traditional Chinese Medicine from January 2022 to April 2024 were selected and divided into the observation group and the control group by random number table method,with 40 cases in each group.The patients in the control group received basic treatment of internal medicine,and no treatment was given to the arteriovenous fistula after 24 hours of hemodialysis performance.The patients in the observation group were evenly smeared with Yilou liniment along the blood vessels on the basis of the treatment in the control group.After 24 weeks of continuous treatment,the clinical efficacy,blood flow volume of the arteriovenous fistula,proximal inner diameter of the puncture site,distal inner diameter of the puncture site,urea clearance index(KT/V),urea reduction rate(URR),levels of interleukin-6(IL-6)and transforming growth factor-β(TGF-β)were compared between the two groups.Results The total effective rate in the observation group was higher than that in the control group;after treatment in the observation group,the blood flow volume of the arteriovenous fistula and distal inner diameter of the puncture site increased,and levels of the both indexes were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the URR increased,while IL-6 and TGF-βdecreased in the observation group;moreover,the URR was significantly higher,while IL-6 and TGF-βlevels were significantly lower in the observation group compared with those in the control group(P<0.05).The total incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusions Yilou liniment has a significant efficacy in the treatment of hemodialysis patients with

关 键 词：益瘘搽剂 动静脉内瘘狭窄 血液透析 内瘘血流量 炎症因子 

分 类 号：R543[医药卫生—心血管疾病]