同型半胱氨酸对高血压患者血压变异性的影响  

Effect of homocysteine on blood pressure variability in hypertensive patients

作　　者：李楠 LI Nan(Department of Laboratory,Tianqiao Campus of Shandong Provincial Third Hospital,Ji'nan Tianqiao People's Hospital,Ji'nan,Shandong 250001,China)

机构地区：[1]山东省立第三医院天桥院区,济南市天桥人民医院检验科,山东济南250001

出　　处：《医药前沿》2025年第13期72-74,共3页Journal of Frontiers of Medicine

摘　　要：目的探讨同型半胱氨酸(Hcy)对高血压患者血压变异性(BPV)的影响。方法回顾性分析2023年1月—2024年6月济南市天桥人民医院收治的120例高血压患者的临床资料。按照血Hcy水平高低分为观察组(血Hcy≥15μmol/L)及对照组(血Hcy<15μmol/L)。比较两组患者实验室指标及入院时血压,分析血Hcy对高血压患者BPV等有关指标的影响。结果观察组血Hcy、入院时舒张压、24 h舒张压、24 h收缩压标准差、24 h舒张压标准差均高于对照组(P<0.05)。结论血Hcy水平升高会加大高血压患者的BPV,因此在高血压治疗期间,应重点关注血Hcy、BPV等各项指标的变化,提高患者血压管理的安全性与有效性。Objective To investigate the effect of homocysteine(Hcy)on blood pressure variability(BPV)in patients with hypertension.Methods The clinical data of 120 hypertensive patients admitted to Ji'nan Tianqiao People's Hospital from January 2023 to June 2024 were retrospectively analyzed.According to the level of Hcy,they were divided into observation group(Hcy≥15μmol/L)and control group(Hcy<15μmol/L).The laboratory indexes and blood pressure at admission were compared between the two groups,and the influence of Hcy on BPV and other related indexes in hypertensive patients was analyzed.Results Blood Hcy,diastolic blood pressure at admission,24 h diastolic blood pressure,24 h systolic blood pressure standard deviation and 24 h diastolic blood pressure standard deviation in observation group were higher than those in control group(P<0.05).Conclusions The increase of blood Hcy level will increase the BPV of patients with hypertension.Therefore,during the treatment of hypertension,we should pay attention to the changes of blood Hcy,BPV and other indicators,so as to improve the safety and effectiveness of blood pressure management of patients.

关 键 词：高血压 同型半胱氨酸 收缩压 舒张压 血压标准差 血压变异性 

分 类 号：R544[医药卫生—心血管疾病]