丙泊酚麻醉对试管婴儿新鲜周期妊娠结局的影响  

Effect of propofol anesthesia on pregnancy outcomes of fresh in vitro fertilization cycles

作　　者：刘言芳 陆翠娥 陈俊杰[1] 黄赛赛[1] 高永涛[1] Liu Yanfang;Lu Cuie;Chen Junjie;Huang Saisai;Gao Yongtao(Department of Anesthesiology,Affiliated Hospital of Nantong University,Nantong 226001,China)

机构地区：[1]南通大学附属医院麻醉科,南通226001

出　　处：《国际麻醉学与复苏杂志》2025年第3期232-240,共9页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金(82101291);南通市科科技计划项目(JCI2022003);南通市卫生健康科技项目(MS2023025)。

摘　　要：目的探讨丙泊酚麻醉对试管婴儿新鲜周期妊娠结局的影响。方法买采用回顾性队列研究方法,共收集320例进入试管婴儿新鲜周期程序患者的临床资料,根据是否使用丙泊酚分为麻醉组(108例)和非麻醉组(212例),采用倾向性评分匹配和logistic多因素回归分析两组患者基线水平资料,探讨丙泊酚麻醉对妊娠结局宫内妊娠率的影响;根据宫内妊娠的结局变量分为宫内妊娠组(155例)和非宫内妊娠组(165例),采用logistic多因素回归分析探究影响宫内妊娠的变量。结果麻醉组和非麻醉组倾向性评分匹配后,两组各纳人91例患者,匹配后两组患者基线水平差异无统计学意义(均P>0.05);麻醉组宫内妊娠率为47.25%,非麻醉组宫内妊娠率为54.95%,两组差异无统计学意义(P>0.05)。非宫内妊娠组及宫内妊娠组进行logistic多因素回归分析比较,两组患者女方年龄、男方年龄、子宫因素、扳机日促黄体生成素水平差异有统计学意义(均P<0.05),两组患者丙泊酚麻醉比例差异无统计学意义(P>0.05)。结论丙泊酚麻醉对试管婴儿宫内妊娠率无明显影响。Objective To investigate the effect of propofol anesthesia on the pregnancy outcomes of fresh in vitro fertilization(IVF)cycles.Methods A retrospective cohort study was conducted.Clinical data were collected from 320 patients with fresh IVF cycles.Based on the use of propofol,the patients were divided into two groups:an anesthesia group(n=108)and a non-anesthesia group(n=212).Then,propensity score matching and logistic multivariate regression analysis were performed to compare the baseline charac-teristics between the two groups and to explore the effect of propofol anesthesia on intrauterine pregnancy rates.According to the out-come of intrauterine pregnancy,the patients were divided into two groups:an intrauterine pregnancy group(n=155)and a non-intrauterine pregnancy group(n=165).Logistic multivariate regression analysis was used to identify variables influencing intrauterine pregnancy.ResultsAfter propensity score matching,91 patients were included in each groups,with no statistical differences in baseline charac-teristics between the two groups(all P>0.05).The intrauterine pregnancy rate was 47.25%in the anesthesia group and 54.95%in the non-anesthesia group,with no statistical difference between the two groups(P>0.05).Logistic multivariate regression analysis was per-formed on the non-intrauterine pregnancy group and the intrauterine pregnancy group.The results revealed statistical differences in fe-male age,male age,uterine factors,and luteinizing hormone levels on trigger day(all P<0.05).Propofol had no significant effect on in-trauterine pregnancy rates(P>0.05).Conclusion Propofol anesthesia does not significantly affect the intrauterine pregnancy rate of IVF.

关 键 词：试管婴儿 新鲜周期 女妊娠结局 市丙泊酚 

分 类 号：R614[医药卫生—麻醉学]