临床药师干预对华法林治疗患者抗凝质量的影响  

Effect of Clinical Pharmacist Intervention on Anticoagulant Quality in Patients Treated with Warfarin

作　　者：张蓉 黄可可 吴超[1] ZHANG Rong;HUANG Ke-ke;WU Chao(Department of Pharmaceutical,Pingxiang People's Hospital,Pingxiang,Jiangxi,337000,China)

机构地区：[1]萍乡市人民医院药学部,江西萍乡337000

出　　处：《现代生物医学进展》2025年第7期1248-1254,共7页Progress in Modern Biomedicine

基　　金：萍乡市科学技术局市级科技计划项目(2021PY075)。

摘　　要：目的:观察临床药师干预对华法林治疗患者抗凝质量的影响。方法:采用随机数字表法,将我院2021年7月至2024年6月期间收治的116例接受口服华法林抗凝治疗的患者分为对照组(n=58)和研究组(n=58),对照组采用常规用药指导,研究组在对照组基础上接受药师干预。对比两组华法林用药知识的认知度、华法林达到稳态时间、用药依从性、出院时国际标准化比值(INR)达标率、INR达标时间、抗凝质量及不良反应发生率。结果:两组干预6个月后华法林用药知识的认知度评分升高,且研究组高于对照组(P<0.05)。与对照组相比,研究组的Morisky服药依从性测量量表(MMAS-8)评分、达标时间百分比(TTR)、出院时INR达标率更高,INR达标时间、华法林达到稳态时间更短,不良反应发生率更低(P<0.05)。结论:临床药师干预用于华法林治疗患者,可有效提高用药依从性,改善抗凝效果,改善华法林用药知识的认知度,降低不良反应发生率。Objective:To observe the effect of clinical pharmacist intervention on the anticoagulant quality of patients treated with warfarin.Methods:Used random number table method,116 patients who received oral warfarin anticoagulant therapy in our hospital from July 2021 to June 2024 were divided into control group( n=58) and study group( n=58),the control group received routine medication guidance,while the study group received pharmacist intervention on the basis of the control group.The cognitive of warfarin medication knowledge score,warfarin reaches steady state time,medication compliance,international normalized ratio( INR) compliance rate and INR compliance rate at discharge,anticoagulation quality and incidence of adverse reactions between two groups were compared.Results:The cognitive of warfarin medication knowledge score at 6 months after intervention increased in both groups,and the study group was higher than that of the control group( P<0.05).Compared with the control group,the morisky medication adherence scale-8( MMAS-8) score,time to compliance( TTR),and INR compliance rate at discharge were higher in the study group,the INR compliance time and warfarin reaches steady state time were shorter,and the incidence of adverse reactions was lower( P<0.05).Conclusion:Clinical pharmacist intervention in patients treated with warfarin can effectively improve medication compliance,enhance anticoagulant efficacy,improve cognitive of warfarin medication knowledge,and reduce the incidence of adverse reactions.

关 键 词：临床药师 华法林 抗凝治疗 依从性 

分 类 号：R3[医药卫生—基础医学] R973.2