GnRH-a长方案与拮抗剂方案在PCOS患者中的临床疗效对比  

Comparison of clinical efficacy between GnRH-a long regimen and antagonist regimen in PCOS patients

作　　者：张梦洁 田海清[1] 热弯 马浩哲 腊晓琳[1] ZHANG Mengjie;TIAN Haiqing;RE Wan;MA Haozhe;LA Xiaolin(Department of The Center of Reproductive Medicine,the First Affiliated Hospital of Xinjiang Medical University,Xinjiang,Urumqi,830054,China)

机构地区：[1]新疆医科大学第一附属医院生殖医学中心,乌鲁木齐830054

出　　处：《新疆医学》2025年第2期125-129,共5页Xinjiang Medical Journal

基　　金：国家自然科学基金(项目编号:81960289);中央引导地方科技发展专项基金项目(项目编号:ZYYD2024ZY07);省部共建中亚高发病成因与防治国家重点实验室(项目编号:SKL-HIDCA-2024-GX2)。

摘　　要：目的分析多囊卵巢综合征(PCOS)患者在体外受精-胚胎移植(IVF/ICSI-ET)助孕治疗中采用不同促排方案治疗后的临床疗效。方法选取2020年1月-2023年12月就诊于新疆医科大学一附院生殖医学中心并接受第一次或第二次IVF/ICSI-ET治疗的PCOS患者病例资料,共376例;根据促排方案分为拮抗剂方案组(A组),GnRH-a长方案组(B组),比较两组患者的临床疗效。结果两组的周期取消率、OHSS发生率、可移植胚胎数及优质胚胎总数差异无统计学意义(P>0.05)。A组的使用Gn天数,Gn总量、获卵数、临床妊娠率均低于B组;A组hCG注射日E2、LH、P的水平均高于B组,差异均有统计学意义(P<0.05)。结论PCOS患者采用GnRH-a长方案与拮抗剂方案治疗后的周期取消率与OHSS发生率无明显差异,GnRH-a长方案的鲜胚移植妊娠率更高。Objective Analysis of the clinical efficacy of different ovulation induction regimens in in vitro fertilization embryo transfer(IVF/ICSI-ET)assisted reproductive therapy for patients with polycystic ovary syndrome(PCOS).Methods Select case data of 376 PCOS patients who received their first or second IVF/ICSI-ET treatment at the Reproductive Medicine Center of the First Affiliated Hospital of Xinjiang Medical University from January 2020 to December 2023;According to the ovulation induction regimen,patients were divided into an antagonist regimen group(Group A)and a GnRH-a long regimen group(Group B),and the clinical efficacy of the two groups was compared.Results There was no statistically significant difference in the cancellation rate,OHSS incidence,number of transplantable embryos,and total number of high-quality embryos between the two groups(P>0.05).The number of days of Gn use,total amount of Gn,number of retrieved eggs,and clinical pregnancy rate in Group A were all lower than those in Group B;On the day of hCG injection,the levels of E2,LH,and P in Group A were higher than those in Group B,and the differences were statistically significant(P<0.05).Conclusion There is no significant difference in the cycle cancellation rate and OHSS incidence between PCOS patients treated with GnRH-a long regimen and antagonist regimen,and the fresh embryo transfer pregnancy rate is higher with GnRHa long regimen.

关 键 词：多囊卵巢综合征 体外受精-胚胎移植 促排方案 临床疗效 

分 类 号：R711[医药卫生—妇产科学]