泌尿生殖道支原体感染对不同妊娠结局的影响  

The impact of urogenital mycoplasma infection on different pregnancy outcomes

作　　者：蒋斓 李一丹 夏燕 张晶 刘雨凌 张梓瑞 李晓勤 JIANG Lan;LI Yidan;XIA Yan;ZHANG Jing;LIU Yuling;ZHANG Zirui;LI Xiaoqin(Department of Laboratory Medicine,Urumqi,830001,China;Department of Assisted Reproduction,Urumqi,830001,China;Gynecological ward,Urumqi Maternal and Child Health Hospital,Urumqi,830001,China;Department of Laboratory Medicine,Urumqi Youai Hospital,Urumqi,831400,China)

机构地区：[1]乌鲁木齐市妇幼保健院检验科,乌鲁木齐830001 [2]乌鲁木齐市妇幼保健院辅助生殖科,乌鲁木齐830001 [3]乌鲁木齐市妇幼保健院妇科,乌鲁木齐830001 [4]乌鲁木齐市友爱医院检验科,乌鲁木齐831400

出　　处：《新疆医学》2025年第2期153-157,共5页Xinjiang Medical Journal

基　　金：吴阶平医学基金会临床科研专项(项目编号:320.6750.18574)。

摘　　要：目的探讨泌尿生殖道支原体感染在稽留流产、先兆流产、异位妊娠者中的患病率及其影响因素。方法回顾性分析2020年1月至2023年1月期间,采用解脲脲原体和人型支原体选择分离固体培养基,检测1342例住院孕妇的泌尿生殖道分泌物标本,其出院诊断为稽留流产、先兆流产、异位妊娠,及同期人工流产中分析支原体感染情况,利用多因素Logistics回归分析泌尿生殖道支原体感染对不同妊娠结局的影响。结果1342例泌尿生殖道标本中支原体阳性411例,阳性率为30.63%,其中单纯解脲脲原体(MH-UU+)350例,占支原体感染阳性构成比85.16%,稽留流产组、先兆流产组、异位妊娠组、人工流产组中支原体感染率分别为29.15%、26.20%、43.18%、32.51%,相比较具有统计学差异(P<0.05)。异位妊娠组中支原体感染率在年龄<35岁、有流产史、妊娠时间(8-12周)均高于稽留流产组、先兆流产组,均有统计学差异(均P<0.008)。年龄对于稽留流产组、先兆流产组、异位妊娠组均为危险因素;与人工流产组比较,支原体感染者发生异位妊娠风险是未感染者的1.675倍(OR=1.675,95%CI=1.032~2.719)。结论泌尿生殖道支原体感染或孕次超过3次均可增加异位妊娠发生风险性,随着年龄增加,发生稽留流产、先兆流产、异位妊娠风险性随之增加。Objective To investigate the prevalence and effect of urogenital mycoplasma infection on missed abortion,threatened abortion and ectopic pregnancy.Methods A retrospective analysis was conducted on the period from January 2020 to January 2023,Urealyticum and mycoplasma selective solid culture media were used to detect urogenital secretions from 1,342 hospitalized pregnant women.The discharge diagnoses included missed abortion,threatened abortion,ectopic pregnancy,and concurrent induced abortion,in order to analyze the incidence of mycoplasma infections.Multivariate logistic regression was utilized to assess the impact of urogenital mycoplasma infections on different pregnancy outcomes.Results Among 1342 urogenital tract specimens,411 cases were Mycoplasma positive,with a positive rate of 30.63%,including 350 cases of Ureaplasma urealyticum(MH-UU+),accounting for 85.16% of mycoplasma infection.The mycoplasma infection rates in missed abortion group,threatened abortion group,ectopic pregnancy group and induced abortion group were 29.15%,26.20%,43.18% and 32.51%respectively(P<0.05).Mycoplasma infection in ectopic pregnancy group was significantly higher than that in missed abortion group and threatened abortion group(P<0.008).Age was a risk factor for missed abortion group,threatened abortion group and ectopic pregnancy group;Compared with the induced abortion group,the risk of ectopic pregnancy in mycoplasma infected individuals was 1.675 times higher than that in the uninfected individuals(OR=1.675,95%CI=1.032~2.719).Conclusion Urogenital mycoplasma infection or more than three pregnancies can increase the risk of ectopic pregnancy.With the increase of age,the risk of missed abortion,threatened abortion and ectopic pregnancy increases.

关 键 词：泌尿生殖道 支原体 稽留流产 先兆流产 异位妊娠 

分 类 号：R375[医药卫生—病原生物学]