LAP和TyG指数对代谢相关脂肪性肝病的预测价值  

The predictive value of LAP and TyG index on metabolism-associated fatty liver disease

作　　者：吴宏伟 申雪琦 杲晓兰 姜志新[4] WU Hongwei;SHEN Xueqi;GAO Xiaolan;JIANG Zhixin(Department of Anesthesiology,The People's Hospital of Shihezi,Shihezi,Xinjiang,832000,China;Ophthalmology Department,The People's Hospital of Shihezi,Shihezi,Xinjiang,832000,China;Department of Physical Examination,The People's Hospital of Shihezi,Shihezi,Xinjiang,832000,China;*Department of General Surgery,The People's Hospital of Shihezi,Shihezi,Xinjiang,832000,China)

机构地区：[1]石河子市人民医院麻醉科,新疆石河子832000 [2]石河子市人民医院眼科,新疆石河子832000 [3]石河子市人民医院健康体检科,新疆石河子832000 [4]石河子市人民医院普外科,新疆石河子832000

出　　处：《新疆医学》2025年第2期178-186,共9页Xinjiang Medical Journal

摘　　要：目的分析脂质蓄积指数(LAP)、甘油三脂/葡萄糖指数(TyG)对代谢相关脂肪性肝病(MAFLD)的预测作用。方法前期纳入2022年10月至2023年10月于新疆石河子市人民医院就诊的患者数据2135条,筛选后分为MAFLD组(454例)和非MAFLD组(1681例),比较两组与LAP、TyG以及各生化指标的差异和相关性,采用logistic回归分析不同校正条件下MAFLD发生风险的OR值及95%CI。绘制不同性别、BMI水平下LAP、TyG、BMI、WC、WHtR预测MAFLD发生的工作特征曲线(ROC)并计算AUC值。结果男性、更高的年龄、吸烟、饮酒是MAFLD的危险因素。LAP、TyG与MAFLD存在中等强度以上的相关性。排除混杂因素,LAP、TyG各第4组的发病率分别是第1组的16倍、9倍,其诊断试验中的一致率达85%以上。不同性别和BMI亚组中LAP、TyG、BMI、WC、WHtR预测MAFLD发生的AUC均>0.7,其中LAP在女性中的AUC值最高为0.911。结论LAP、TyG与MAFLD密切相关,其在女性和BMI≤23的人群中对MAFLD的发生具有良好预测效果。Objective To analyze the predictive effects of lipid accumulation index(LAP)and triglyceride-glucose index(TyG)on metabolism-related fatty liver disease(MAFLD).Methods 2135 patient data from October 2022 to October 2023 in People's Hospital of Shihezi of Xinjiang were included in the initial stage,and were divided into MAFLD group(454 cases)and non-MAFLD group(1681cases)after screening.The differences and correlation between the two groups and LAP,TyG and various biochemical indicators were compared.The OR value and 95%CI of the risk of MAFLD under different correction conditions were analyzed by logistic regression.The operating characteristic curve(ROC)of LAP,TyG,BMI,WC and WHtR for predicting the occurrence of MAFLD under different sex and BMI levels was plotted and the AUC value was calculated.Results Male,higher age,smoking and drinking were the risk factors for MAFLD.The correlation between LAP,TyG and MAFLD was above moderate intensity.Excluding confounding factors,the incidence of LAP and TyG in group 4 was 16 times and 9 times higher than that in group 1,respectively,and the concordance rate in diagnostic tests was more than 85%.The AUC of LAP,TyG,BMI,WC and WHtR to predict the occurrence of MAFLD in different gender and BMI subgroups were all>0.7,and the AUC of LAP in females was the highest at 0.911.Conclusion LAP and TyG are closely related to MAFLD,and they have good predictive effect on the occurrence of MAFLD in women and BMI≤23 population.

关 键 词：代谢相关脂肪性肝病 脂质蓄积指数 甘油三脂/葡萄糖指数 

分 类 号：R589.2[医药卫生—内分泌]