达格列净联合利拉鲁肽治疗肥胖2型糖尿病的效果  

Efficacy of daglipzin combined with Liraglutide in the treatment of obese type2 diabetes mellitus

作　　者：司晓萌 SI Xiaomeng(Department of Internal Medicine,Hospital of Traditional Chinese Medicine of Modern Medicine Institute of Henan Zhengzhou,450000,China)

机构地区：[1]河南(郑州)现代医学研究院中医院内科,郑州450000

出　　处：《新疆医学》2025年第2期191-194,243,共5页Xinjiang Medical Journal

摘　　要：目的探究达格列净+利拉鲁肽强化治疗肥胖2型糖尿病(T2DM)且血糖控制不佳患者的效果。方法选取病例为本院2022年2月至2023年6月收治的72例血糖控制不佳的T2DM肥胖患者。遵循随机数字表路径划分成观察组(36例)、对照组(36例)。对照组以利拉鲁肽治疗,观察组以达格列净+利拉鲁肽治疗,均连治12周。比较血糖参数(空腹血糖、2h PBG、HbAlc)、肥胖参数(BMI、腰围)、胰岛功能参数(HOMA-IR、HOMA-β)、氧化应激(SOD、MDA)。结果治疗后,空腹血糖、2h PBG、HbAlc在观察组[(5.98±0.74)mmol/L、(7.89±1.02)mmol/L、(6.32±0.74)%]水平较于对照组[(6.73±0.82)mmol/L、(8.73±1.13)mmol/L、(7.48±0.91)%]均显然更低(P<0.05)。治疗后,观察组BMI、腰围[(27.24±1.29)kg/m^(2)、(96.33±4.28)cm]较于对照组[(28.23±1.67)kg/m^(2)、(103.42±4.76)cm],水平均更低(P<0.05)。治疗后,观察组HOMA-IR、MDA低于对照组,HOMA-β、SOD高于对照组(P<0.05)。结论血糖控制不佳的T2DM肥胖患者接受达格列净+利拉鲁肽强化治疗可有效降低血糖水平,改善肥胖状态,调节胰岛功能,抑制氧化应激。Objective To explore the effect of dapagliflozin+liraglutide intensive treatment on obese patients with type 2 diabetes mellitus(T2DM)and poor blood glucose control.Methods Seventy-two obese patients with T2DM and poor blood glucose control admitted to our hospital from February 2022 to June 2023 were selected.According to the random number table path,they were divided into the observation group(36 cases)and the control group(36 cases).The control group was treated with liraglutide,and the observation group was treated with dapagliflozin+liraglutide;all patients were treated for 12 weeks.Blood glucose parameters(fasting blood glucose,2h PBG,HbAlc),obesity parameters(BMI,waist circumference),islet function parameters(HOMA-IR,HOMA-β),oxidative stress(SOD,MDA)were compared.Results After treatment,the levels of fasting blood glucose,2h PBG and HbAlc in the observation group[(5.98±0.74)mmol/L,(7.89±1.02)mmol/L,(6.32±0.74)%]were lower than those in the control group[(6.73±0.82)mmol/L,(8.73±1.13)mmol/L,(7.48±0.91)%](P<0.05).After treatment,the levels of BMI and waist circumference in the observation group[(27.24±1.29)kg/m^(2),(96.33±4.28)cm]were lower than those in the control group[(28.23±1.67)kg/m^(2),(103.42±4.76)cm](P<0.05).After treatment,HOMA-IR and MDA in observation group were lower than those in control group,while HOMA-βand SOD were higher than those in control group(P<0.05).Conclusion Dapagliflozin combined with liraglutide intensive therapy can effectively reduce blood glucose level,improve obesity status,regulate islet function and inhibit oxidative stress in poorly blood glucose controlled obese T2DM patients.

关 键 词：2型糖尿病 肥胖 血糖控制不佳 达格列净 利拉鲁肽 氧化应激 

分 类 号：R587.1[医药卫生—内分泌]