HMGB1:急性肺损伤“肺-脑轴”炎症关联的关键介质与治疗新靶标  

HMGB1:a critical mediator and novel therapeutic target in the"lung-brain axis"inflammatory connection of acute lung injury

作　　者：朱丽玲 肖婷 屈双权 Zhu Liling;Xiao Ting;Qu Shuangquan(Department of Anesthesiology,Hunan Children’s Hospital,School of Pediatrics,Hengyang Medical School,University of South China,Changsha 410007,China;Department of Anesthesiology,Affiliated Children’s Hospital,Xiangya School of Medicine,Central South University(Hunan Children’s Hospital),Changsha 410007,China)

机构地区：[1]南华大学衡阳医学院儿科学院湖南省儿童医院麻醉手术科,长沙410007 [2]中南大学湘雅医学院附属儿童医院湖南省儿童医院麻醉手术科,长沙410007

出　　处：《临床小儿外科杂志》2025年第3期288-291,共4页Journal of Clinical Pediatric Surgery

基　　金：湖南省自然科学基金面上项目(2024JJ5220)。

摘　　要：急性肺损伤及其重症形式急性呼吸窘迫综合征均是高病死率的肺部疾病,常伴脑损伤,严重影响治疗与预后。炎症机制在急性肺损伤“肺-脑轴”中起关键作用,细胞外高迁移率族蛋白B1(high mobility group box1 protein,HMGB1)作为重要的促炎因子,广泛参与肺、脑损伤的发病过程。抑制HMGB1释放有望阻断肺-脑炎症沟通,为攻克肺脑共损伤提供新思路与治疗靶点。Acute lung injury(ALI)and its more severe form,acute respiratory distress syndrome(ARDS),are lung diseases with high mortality rates.They are often complicated by brain injury,significantly affecting treatment and prognosis.Inflammatory plays a pivotal role in the"lung-brain axis"of ALI.As a critical pro-inflammatory factor,extracellular high mobility group box 1 protein(HMGB1)is widely implicated in the pathogenesis of both pulmonary and cerebral injuries.Inhibiting HMGB1 release is expected to disrupt inflammatory crosstalk between the lung and brain,offering novel insights and potential therapeutic targets for mitigating combined lung and brain damage.

关 键 词：HMGB1 急性肺损伤 肺-脑轴 脑损伤 

分 类 号：R563[医药卫生—呼吸系统]