孕早期血糖联合超敏C反应蛋白检测在妊娠期糖尿病预后评估中的应用研究  

Application of early pregnancy blood glucose combined with high-sensitivity Creactive protein detection in the prognosis evaluation of diabetes in pregnancy

作　　者：陈诚星 王永红[1] Chen Chengxing;Wang Yonghong(The First People’s Hospital of Chenzhou City,Chenzhou,Hunan 423000,China)

机构地区：[1]湖南省郴州市第一人民医院,湖南郴州423000

出　　处：《首都食品与医药》2025年第9期42-44,共3页Capital Food Medicine

基　　金：郴州市技术创新引导项目(编号:lcyl2021032)。

摘　　要：目的 探讨孕早期血糖联合超敏C反应蛋白(hs-CRP)检测在妊娠期糖尿病(GDM)预后评估中的应用价值。方法 选取本院2022年9月-2024年9月诊治的50例GDM患者作为GDM组,另选取本院同时期行常规孕检的50例健康妊娠期女性作为健康组,两组均行孕早期血糖及hs-CRP检测,对比其检测值与阳性检出率。以临床诊断结果为金标准,比较孕早期血糖、hs-CRP单项检测与联合检测对GDM的诊断价值。对GDM患者随访至分娩后,分析不良妊娠结局发生率;将发生不良妊娠结局者纳入预后不良组,将未发生不良妊娠结局者纳入预后良好组,对比两组的孕早期血糖、hs-CRP检测结果;绘制ROC曲线,评估孕早期血糖、hs-CRP单项检测与联合检测对GDM预后的评估价值。结果 GDM组的空腹血糖、餐后2h血糖、hs-CRP均高于健康组,P<0.05;GDM组孕早期血糖、hs-CRP的阳性检出率均高于健康组,P<0.05。联合检测对GDM诊断的准确性高于血糖单项检测,准确性、敏感度均高于hs-CRP单项检测,P<0.05。50例GDM患者中,羊水过多5例,晚期流产1例,早产4例,妊娠高血压2例,不良妊娠结局发生率为24.00%(12/50)。预后不良组的空腹血糖、餐后2h血糖、hs-CRP均高于预后良好组,P<0.05。联合检测对GDM预后评估的AUC、灵敏度、特异度高于血糖、hs-CRP单项检测。结论 孕早期血糖、hs-CRP在GDM患者中呈高表达水平,其联合检测可以进一步提高GDM诊断结果的准确率,且对患者预后评估具有一定的评估价值。Objective To explore the value of early pregnancy blood glucose combined with high-sensitivity C-reactive protein(hs-CRP)in the prognostic evaluation of gestational diabetes(GDM).Methods Fifty patients with gestational diabetes mellitus(GDM)treated in our hospital from September 2022 to September 2024(GDM group)were selected,and another fifty healthy pregnant women who underwent routine pregnancy tests at the same time in our hospital(healthy group)were selected.Both groups underwent early pregnancy blood glucose and hs-CRP testing,and their detection values were compared with the positive detection rate.Using clinical diagnostic results as the gold standard,compare the diagnostic value of early pregnancy blood glucose,hs-CRP single detection,and combined detection for GDM.Follow up of GDM patients until delivery to analyze the incidence of adverse pregnancy outcomes;include those who experience adverse pregnancy outcomes in the poor prognosis group and those who do not experience adverse pregnancy outcomes in the good prognosis group,and compare the early pregnancy blood glucose and hs-CRP test results between the two groups;draw ROC curves to evaluate the prognostic value of early pregnancy blood glucose,hs-CRP single and combined detection for GDM.Results Fasting blood glucose,2-hour postprandial blood glucose,and hs-CRP in the GDM group were all higher than those in the healthy group,P<0.05;the positive detection rates of early pregnancy blood glucose and hs-CRP in the GDM group were higher than those in the healthy group,P<0.05.The accuracy of combined testing for GDM diagnosis is higher than that of single blood glucose testing,and both accuracy and sensitivity are higher than those of single hs-CRP testing,P<0.05.Among 50 GDM patients,there were 5 cases of polyhydramnios,1 case of late miscarriage,4 cases of premature birth,2 cases of gestational hypertension,and an incidence of adverse pregnancy outcomes of 24.00%(12/50).The fasting blood glucose,2-hour postprandial blood glucose,and hs-CRP levels in the

关 键 词：孕早期 血糖 超敏C反应蛋白 妊娠期糖尿病 预后 

分 类 号：R714.256[医药卫生—妇产科学]