羟考酮在内窥镜下结石取出术麻醉中的应用  

Application of oxycodone in endoscopic stone removal anesthesia

作　　者：张小丹[1] 程芳[1] 李日长[1] 李树智 萧燕萍 刘湘杰[1] Zhang Xiaodan;Cheng Fang;Li Richang;Li Shuzhi;Xiao Yanping;Liu Xiangjie(Jiangmen Central Hospital,Jiangmen,Guangdong 529000,China)

机构地区：[1]广东省江门市中心医院,广东江门529000

出　　处：《首都食品与医药》2025年第9期58-61,共4页Capital Food Medicine

基　　金：恩泽疼痛管理医学研究项目(编号:ezmr2022-035)。

摘　　要：目的 探究羟考酮在内窥镜下结石取出术麻醉中的应用。方法 选择2022年4月-2024年10月在我院行内窥镜下结石取出术患者120例,根据麻醉方式随机分为两组:羟考酮组及对照组,开展过程中脱落9例,采用羟考酮为羟考酮组(56例),采用常规硬膜外阻滞诱导及维持为对照组(55例),比较两组患者麻醉前(T_(1))、术中(T_(2))、术后即时(T_(3))、术后第一天(T_(4))4个时间点的平均动脉压(MAP)、心率(HR)、血糖值(GLU)、VAS评分值变化、不良反应发生率及患者术后满意度比较。结果 两组T_(2)、T_(3)、T_(4)时MAP水平明显低于T_(1),对照组T_(3)时MAP明显低于T_(2)(P<0.05);羟考酮组T_(2)、T_(4)时HR明显低于T_(1),羟考酮组T_(4)时HR明显高于T_(2),对照组T_(2)、T_(3)、T_(4)时HR明显低于T_(1)(P<0.05);羟考酮组T_(2)、T_(3)时GLU水平明显高于对照组,对照组T_(4)时GLU水平明显高于T_(1)、T_(2)、T_(3)(P<0.05);羟考酮组T_(2)时VAS评分明显高于对照组,羟考酮组T_(3)时VAS评分明显低于T_(1)、T_(2),羟考酮组T_(4)时VAS评分明显高于T_(3),对照组T_(3)时VAS评分明显低于T_(1),对照组T_(4)时VAS评分明显高于T_(3)(P<0.05);羟考酮组不良反应总发生率3.57%明显低于对照组的16.36%(P<0.05);羟考酮组满意率98.21%明显高于对照组的81.32%(P<0.05)。结论 羟考酮在内窥镜下结石取出术麻醉中具有一定的安全性,可平稳患者血流动力学,提高患者术后满意度。Objective To explore the application of oxycodone in endoscopic stone removal anaesthesia.Methods 120 patients were selected for endoscopic stone removal surgery in our hospital from April 2022 to October 2024,and were randomly divided into two groups according to the anaesthesia:oxycodone group and control group,9 cases were dislodged during the process,56 cases were in the oxycodone group using oxycodone,and 55 cases were in the control group using the induction and maintenance of conventional epidural block,and the mean arterial pressure(MAP)of the patients in the two groups at four time points,namely,before anaesthesia(T_(1)),during the procedure(T_(2)),immediately after the procedure(T_(3)),and the first day of the procedure(T_(4)),was compared,immediate postoperative(T_(3)),and the first postoperative day(T_(4)),the mean arterial pressure(MAP),heart rate(HR),blood glucose value(GLU),VAS score value changes,complication rate and patient satisfaction after the operation were compared between the two groups.Results MAP levels were significantly lower than T_(1) at T_(2),T_(3),and T_(4) in both groups,and significantly lower than T_(2) at T_(3) in the control group(P<0.05);HR was significantly lower than T_(1) at T_(2) and T_(4) in the oxycodone group,significantly higher than T_(2) at T_(4) in the oxycodone group,and significantly lower than T_(1) at T_(2),T_(3),and T_(4) in the control group(P<0.05);the GLU levels in the oxycodone group were significantly higher at T_(2) and T_(3) than in the control group,and the GLU levels in the control group were significantly higher at T_(4) than at T_(1),T_(2),T_(3)(P<0.05);the VAS score of the oxycodone group at T_(2) was significantly higher than that of the control group,while the VAS score of the oxycodone group at T_(3) was significantly lower than that of T_(1) and T_(2),the VAS score in the oxycodone group was significantly higher at T_(4) than at T_(3),while the VAS score in the control group was significantly lower at T_(3) than at T_(1),the VAS score in the co

关 键 词：羟考酮 超微通道经皮肾镜手术 麻醉 

分 类 号：R614[医药卫生—麻醉学]