仿生物电刺激联合雌孕激素序贯治疗卵巢早衰患者的效果及对子宫动脉血流动力学的影响  

Therapeutic effect of biomimetic electrical stimulation combined with sequential treatment of estrogen and progesterone on premature ovarian failure and its influence on uterine artery hemodynamics

作　　者：张蕾 樊雅芝 赵晓娟 Zhang Lei;Fan Yazhi;Zhao Xiaojuan(Department of Gynecology,the First People's Hospital of Xianyang,Xianyang 712000,China)

机构地区：[1]陕西省咸阳市第一人民医院妇科,咸阳712000

出　　处：《中国综合临床》2025年第2期93-98,共6页Clinical Medicine of China

基　　金：陕西省社会发展科技攻关项目(2021SF-047)。

摘　　要：目的探究仿生物电刺激联合雌孕激素序贯治疗卵巢早衰患者的效果及对子宫动脉血流动力学的影响。方法选取2022年12月至2023年12月咸阳市第一人民医院收治的90例卵巢早衰患者,根据组间基线特征匹配的原则,采用随机摸粉黑球的方式分为观察组(粉球,45例)和对照组(黑球,45例),其中对照组接受雌孕激素序贯疗法,观察组则在对照组的基础上增加仿生物电刺激技术结合治疗。比较两组患者治疗效果、性激素水平[卵泡刺激素(follicle-stimulating hormone,FSH)、黄体生成素(luteinizing hormone,LH)、雌二醇]、子宫动脉血流动力学指标[子宫动脉收缩期峰值流速(peak systolic velocity,PSV)、搏动指数、阻力指数]和不良反应发生情况。符合正态分布的计量数据以x¯±s表示,组间均数对比采用独立样本t检验,治疗前后比较采用配对t检验;计数数据计算百分率,组间百分率比较通过χ^(2)检验。P<0.05为差异有统计学意义。结果观察组患者的总有效率为96.56%(43/45),高于对照组的82.22%(37/45),差异有统计学意义(χ^(2)=4.05,P=0.044)。治疗结束后,两组患者FSH、LH、搏动指数、阻力指数指标水平均降低,但观察组患者的上述指标结果依次为(35.12±6.23)U/L、(33.56±4.12)U/L,1.97±0.59、0.41±0.13,均低于对照组[(49.23±6.87)U/L、(46.25±4.32)U/L,2.33±1.04、0.58±0.22];而两组患者的雌二醇和PSV指标水平均增加,且观察组患者的两项指标水平分别为(38.23±5.32)ng/L、(19.68±3.25)cm/s,均高于对照组[(32.12±5.12)ng/L、(16.44±2.03)cm/s],上述指标组间差异均有统计学意义(t值分别为10.21、2.52、2.02、4.62、5.55、5.67,P值分别为<0.001、0.014、0.046、<0.001、<0.001、<0.001)。观察组与对照组患者的不良反应分别为恶心呕吐(3例与4例)、头痛(2例与4例)、乳房胀痛(1例与3例)、腹痛(2例与4例),其发生率比较差异均无统计学意义(χ^(2)值分别为0.16、0.71、1.05、0.71ObjectiveTo explore the therapeutic effectiveness of using biomimetic electrical stimulation in conjunction with hormone replacement therapy involving estrogen and progesterone sequentially on premature ovarian failure and its influence on uterine artery hemodynamics.Methods90 patients with premature ovarian failure in the First People's Hospital of Xianyang were selected from December 2022 to December 2023.According to the principle of matching the baseline characteristics between groups,the above patients were divided into observation group(pink ball,45 cases)and control group(black ball,45 cases)by random touching pink-black ball.The control group received estrogen-progesterone sequential therapy.In contrast,the observation group added biomimetic electrical stimulation combined therapy on the basis of the control group.The therapeutic effect,sex hormones(follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol),uterine artery hemodynamics indicators(uterine artery peak systolic velocity(PSV),pulsatility index(PI),resistance index)and occurrence of adverse reactions were compared between groups of patients.Measurement data with normal distribution were expressed as x¯±s,and independent sample t test was used for between-group comparison of mean data and paired t-test was used for comparison before and after treatment.The percentage of enumeration data was calculated,and between-group rate was compared by chi-square test.P<0.05 was considered statistically significant.ResultsTotal effective rate with 96.56%(43/45)in observation group was higher than 82.22%(37/45)in control group(χ^(2)=4.05,P=0.044).After the end of treatment,FSH,LH,PI and resistance index in both groups were decreased,but the above indicators in observation group((35.12±6.23)U/L,(33.56±4.12)U/L,1.97±0.59,0.41±0.13)were lower than those in control group((49.23±6.87)U/L,(46.25±4.32)U/L,2.33±1.04,0.58±0.22),while the estradiol and PSV in both groups were increased,and the two indicators in observation group((38.23±5.32)ng/L,(

关 键 词：卵巢早衰 仿生物电刺激 雌孕激素序贯治疗 子宫动脉血流动力学 

分 类 号：R711.75[医药卫生—妇产科学]