梅尼埃病:多因素交互导致的内耳疾病  

Meniere’s disease:an inner ear disease caused by multiple factors

作　　者：蒋怀礼 黄新生[1,2] JIANG Huaili;HUANG Xinsheng(Department of Otolaryngology Head and Neck Surgery,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Vertigo Center,Zhongshan Hospital,Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学附属中山医院耳鼻咽喉头颈外科,上海200032 [2]复旦大学附属中山医院眩晕诊疗中心,上海200032

出　　处：《中国临床医学》2025年第2期161-164,共4页Chinese Journal of Clinical Medicine

基　　金：国家重点研发计划“常见多发病防治研究”重点专项(2023YFC2508000/8005)。

摘　　要：梅尼埃病(Meniere’s disease,MD)是一种以反复发作性眩晕、波动性听力下降、耳鸣及耳胀满感为特征的内耳疾病。其发病机制尚未阐明,目前认为与内淋巴积水(endolymphatic hydrops,EH)密切相关,并涉及免疫异常、遗传易感性、血管功能障碍及病毒感染等,是多因素交互作用的结果。本文对近年MD发病机制研究进展作一综述,提出MD可能为一种异质性疾病的论点,认为不同亚型MD的发病机制存在差异,未来需结合多组学分析及动物模型进一步探讨相关分子通路。Meniere’s disease(MD)is an inner ear disorder characterized by recurrent vertigo,fluctuating hearing loss,tinnitus,and aural fullness.The pathogenesis of MD remains unclear but is closely associated with endolymphatic hydrops(EH),immune dysregulation,genetic predisposition,vascular dysfunction,and viral infection.This review summarizes recent research advances of MD pathogenesis,suggesting that MD may be a heterogeneous condition with distinct subtypes driven by different mechanisms.Future studies should integrate multi-omics analyses and animal models to elucidate its molecular pathways.

关 键 词：梅尼埃病 内淋巴积水 免疫机制 遗传因素 多因素交互 

分 类 号：R764.33[医药卫生—耳鼻咽喉科]