中医药调控TRPV1信号通路和相关因子防治带状疱疹及后遗神经痛的研究现状  

Research status of the modulation of TRPV1 signaling pathway and related factors by traditional Chinese medicine for the treatment of herpes zoster and postherpetic neuralgia

作　　者：谢小涛 牛凡琪 潘钰晶 何世烨 王思农 周文丽 XIE Xiao-tao;NIU Fan-qi;PAN Yu-jing;HE Shi-ye;WANG Si-nong;ZHOU Wen-li(School of Clinical Chinese Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu Province,China;Department of Dermatology,Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730000,Gansu Province,China)

机构地区：[1]甘肃中医药大学中医临床学院,甘肃兰州730000 [2]甘肃中医药大学附属医院皮肤科,甘肃兰州730000

出　　处：《中国临床药理学杂志》2025年第3期433-437,共5页The Chinese Journal of Clinical Pharmacology

基　　金：国家重点研发计划“中医药现代化研究”重点专项基金资助项目(2018YFC1705301、2018YFC1705302)。

摘　　要：瞬时受体电位香草酸亚型1(TRPV1)信号通路与带状疱疹(HZ)及带状疱疹后遗神经痛(PHN)的关系密切。中医药在多个方面参与调控TRPV1信号通路,通过调控TRPV1相关神经肽及炎性因子异常释放,神经源性炎症反应等方面治疗HZ及PHN。本文对近年来中医药调控TRPV1信号通路治疗HZ及PHN的机制和作用进行总结,旨在为HZ及PHN的治疗和药物研发提供新思路。The transient receptor potential vanilloid subtype 1(TRPV1)signaling pathway is closely related to herpes zoster(HZ)and postherpetic neuralgia(PHN).Traditional Chinese medicine(TCM)has been involved in regulating the TRPV1 signaling pathway in several ways,and has been used to treat HZ and PHN by modulating the aberrant release of TRPV1-associated neuropeptides and inflammatory factors,and neurogenic inflammatory response,etc.This paper summarizes the mechanism and role of TCM in regulating TRPV1 signaling pathway in the treatment of HZ and PHN in recent years,which will provide new ideas for the treatment of HZ and PHN and drug development.

关 键 词：中医药 带状疱疹及后遗神经痛 瞬时受体电位香草酸亚型1 炎症因子 皮肤神经源性炎症 

分 类 号：R28[医药卫生—中药学]