Notch信号通路在类风湿关节炎病理机制中的研究现状  

Research status of the Notch signaling pathway in the pathogenesis of rheumatoid arthritis

作　　者：漆文霞 王嘉 贺童 田杰祥 王涛 闫彦峰 张媛媛 王钢 QI Wen-xia;WANG Jia;HE Tong;TIAN Jie-xiang;WANG Tao;YAN Yan-feng;ZHANG Yuan-yuan;WANG Gang(School of Traditional Chinese and Western Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu Province,China;Departmentof Rheumatology and Orthopedics,Afiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730020,Gansu Province,China;Departmentof Respiratory and Critical Care Medicine,Fourth Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730060,Gansu Province,China)

机构地区：[1]甘肃中医药大学中西医结合学院,甘肃兰州730000 [2]甘肃中医药大学附属医院风湿骨病科,甘肃兰州730020 [3]甘肃中医药大学第四附属医院呼吸与危重症医学科,甘肃兰州730060

出　　处：《中国临床药理学杂志》2025年第3期438-441,共4页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(81860858、81960832);甘肃省科技基金资助项目(22JR11RA131)。

摘　　要：类风湿关节炎(RA)在中医学属归属于“痹证”“历节病”等范畴,肝肾不足,髓不能养骨,感受外邪,长期郁结于体内,化热成毒,损及气血经络,热毒痰浊瘀血痹阻而发病,虚实夹杂,缠绵难愈。Notch信号通路与本病具有较大的相关性,其参与了炎性细胞浸润、成纤维样滑膜细胞的增殖、微血管的形成及骨质破坏等多种病理过程。本文从中西医结合的角度,基于中医虚、毒、瘀的病机理论,深入探讨Notch信号通路与本病的相关性,以期为研究提供新思路。Rheumatoid arthritis(RA)is categorized as"bi zheng"and"li-jiebing"in Chinese medicine.Liver and kidney insufficiency,marrow can not nourish the bones,feel the external evil,long-term accumulation in the body,heat into poison,damage to the qi and blood meridians and collaterals,heat and poison,phlegm,blood stasis and paralysis and the onset of the disease,mixed with the real and the imaginary,difficult to be cured.The Notch signaling pathway has a greater relevance to this disease,and it is involved in various pathological processes such as inflammatory cell infiltration,proliferation of fibroblast-like synoviocytes(FLS),microvascular formation and bone destruction.In this paper,the correlation between Notch signaling pathway and this disease is discussed from the perspective of the combination of Chinese and Western medicine,based on the theory of"XU,DU,YU"of traditional Chinese medicine,with the aim of providing a new way of thinking for the research.

关 键 词：类风湿关节炎 NOTCH信号通路 虚毒瘀 中西医结合 

分 类 号：R28[医药卫生—中药学]