纤维基有机电化学晶体管葡萄糖传感器的制备及性能研究  

Preparation and Performance Study of Fiber-based Organic Electrochemical Transistor Glucose Sensor

作　　者：李劲松 杨思蕊 孙世民 李中波 张利君 LI Jingsong;YANG Sirui;SUN Shimin;LI Zhongbo;ZHANG Lijun(Anhui Provincial Engineering Center for High-Performance Biobased Nylons,Anhui Engineering Research Center for Highly Functional Fiber Products for Automobiles,School of Materials and Chemistry,Anhui Agricultural University,Hefei 230006,China)

机构地区：[1]安徽省高性能生物基尼龙工程中心,安徽省汽车用高功能纤维产品工程研究中心,安徽农业大学材料与化学学院,合肥230006

出　　处：《高等学校化学学报》2025年第5期37-46,共10页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:52403218);安徽高校自然科学研究项目(批准号:KJ2021A0131);安徽农业大学大学生创新训练项目(批准号:X202410364365)资助.

摘　　要：纤维基有机电化学晶体管具有柔性可穿戴、工作电压低、灵敏度高和生物相容性好等优点,在可穿戴电子器件及生物传感领域应用前景广阔.本文以棉纤维为电极原料,利用石墨烯(Gr)以及聚(3,4-乙撑二氧噻吩)-聚对苯乙烯磺酸钠(PEDOT∶PSS)对纤维表面进行改性,在纤维表面形成一层PEDOT∶PSS/Gr膜,所得聚(3,4-乙撑二氧噻吩)-聚对苯乙烯磺酸钠/石墨烯/纤维(PEDOT∶PSS/Gr/fiber)的电阻低至60Ω/cm.将该导电纤维组装成有机电化学晶体管器件,并在器件的栅极修饰葡萄糖氧化酶,获得的有机电化学晶体管传感器具有稳定的输出性能和高灵敏度,在1 pmol/L~10μmol/L的浓度范围内对葡萄糖检测具有良好的线性响应,且检出限低至1 pmol/L.此外,该传感器对葡萄糖检测具有明显特异性,能够抵抗体液中常见干扰物尿酸、抗坏血酸和常见金属离子(K^(+),Na^(+),Mg^(2+))的干扰.将其用于唾液样品的检测,回收率为87.2%~110%.该研究为糖尿病患者的无创血糖检测提供了一定的参考和技术支持.Fiber-based organic electrochemical transistors have broad application prospects in the fields of wearable electronic devices and biosensors due to the advantages of being flexible and wearable,low working voltage,high sensitivity,and good biocompatibility.In this study,cotton fiber was used as the raw material for electrodes,and graphene(Gr)and poly(3,4-ethylenedioxythiophene)-sodium polystyrene sulfonate(PEDOT∶PSS)were used to modify the fiber surface to form a layer of PEDOT∶PSS/Gr film on the fiber surface.The resistance of the poly(3,4-ethylenedioxythiophene)-sodium polystyrene sulfonate/graphene/fiber(PEDOT∶PSS/Gr/fiber)was as low as 60Ω/cm.An organic electrochemical transistor device with stable output performance and high sensitivity was constructed by PEDOT∶PSS/Gr/fiber,and showed good linear response to glucose detection in the range of 1 pmol/L—10μmol/L,with a detection limitation of 1 pmol/L.In addition,it is demonstrated that the sensor can resist interference from uric acid,ascorbic acid,and common metal ions(K^(+),Na^(+),Mg ^(2+)),which are common interferences in body fluids.The recovery rate was 87.2%-110%when used to detect saliva samples.This study can provide some technical support for non-invasive detection of blood glucose in diabetes.

关 键 词：纤维基有机电化学晶体管 传感器 葡萄糖 无创检测 

分 类 号：O657[理学—分析化学]