头孢特仑体外抗菌作用研究  

Research on the in vitro antibacterial effect of cefteram

作　　者：刘姚姚 薛峰[1] 李耘[1] LIU Yao-yao;XUE Feng;LI Yun(Institute of Clinical Pharmacology,Peking University First Hospital,Bejing 100034,China)

机构地区：[1]北京大学第一医院临床药理研究所,北京100034

出　　处：《中国临床药理学杂志》2025年第5期646-653,共8页The Chinese Journal of Clinical Pharmacology

摘　　要：目的评价头孢特仑对近3年临床常见分离菌的体外抗菌活性。方法收集临床分离细菌,用标准微量肉汤二倍稀释法测定最低抑菌浓度(MIC)。结果对2021—2023年全国范围内临床分离484株细菌进行了MIC测定。结果显示头孢特仑对除青霉素耐药肺炎链球菌(青霉素MIC≥2 mg·L^(-1))外的其他链球菌属细菌均有很好抗菌活性,MIC90值≤1 mg·L^(-1),细菌敏感率为100.0%,与青霉素相似,略优于头孢泊肟,优于头孢呋辛、头孢克肟、头孢克洛和头孢氨苄。革兰氏阴性菌中,头孢特仑对超广谱β内酰胺酶(ESBLs)阴性大肠埃希菌、肺炎克雷伯菌、奇异变形杆菌以及流感嗜血杆菌,卡他莫拉菌同样具有很好抗菌作用,MIC90值≤2 mg·L^(-1),敏感率为100.0%。其中对流感嗜血杆菌,头孢特仑优于全部对照药;对其他革兰氏阴性菌,与头孢泊肟相似,优于头孢呋辛、头孢克洛和头孢氨苄。对于厌氧菌中消化链球菌属,头孢特仑与头孢呋辛相似,优于其他对照药。结论头孢特仑对国内近年临床分离常见革兰氏阳性、阴性及厌氧菌具有广泛、均衡抗菌作用,对青霉素中介、氨苄西林耐药流感嗜血杆菌保存较好活性,为口服头孢菌素中较好品种。Objective To evaluate thein vitroantibacterial activity of cefteram against common clinically isolated bacteria in the past three years.Methods The clinical isolates were collected and the minimal inhibitory concentration(MICs)were determined by the microdilution method.Results A total of 484 pathogenic bacteria over the period2021-2023 were studied.The results show that cefteram has good antibacterial activity againstStreptococcus sppother than penicillinresistantStreptococcus pneumoniae(MICs of penicillin≥2 mg·L^(-1)),MIC_(90)value of cefteram was less than or equal 1 mg·L^(-1),and the susceptibility rate was 100.0%,which was similar to penicillin,slightly better than cefpodoxime,better than cefuroxime,cefixime,cefaclor and cefalexin.Against gram-negative bacteria,cefteram also showed better antibacterial activity,especially againstβ-lactamase(ESBLs)negative Escherichia coli,Klebsiella pneumoniae,Proteus mirabilisandHaemophilus influenzae,andMoraxella catarrhalis.The MIC_(90)value of cefteram was≤2 mg·L^(-1),and the susceptibility rate was 100.0%.Especially for Hemophilus influenzae,cefteram was better than all comparator agents,were comparable to cefpodoxime,better than cefuroxime,cefaclor and cefalexin.ForPeptostreptococcus spp.,cefteram was comparable to cefuroxime,better than all compared agents.Conclusion Cefteram had a wide and balanced antibacterial against clinical isolatied of gram-negative bacteria,gram-positive bacteria and anaerobic bacteria in China in recent years.Cefteram also showed better antibacterial activity,especially against penicillin intermediate and ampicillin-resistantHemophilus influenzae,and is a good variety among oral cephalosporins.

关 键 词：头孢特仑 口服头孢菌素 最低抑菌浓度 体外 

分 类 号：R978.1[医药卫生—药品]