Sirtuins在肝星状细胞能量代谢中的作用  

Roles of Sirtuins in energy metabolism of hepatic stellate cells

作　　者：尹晓春 陈璐[1] 施瑞华[1] YIN Xiao-chun;CHEN Lu;SHI Rui-hua(Department of Gastroenterology,Zhongda Hospital,Medical School,Southeast University,Nanjing 210009,Jiangsu Province,China)

机构地区：[1]东南大学附属中大医院消化科,江苏南京210009

出　　处：《中国临床药理学杂志》2025年第5期732-736,共5页The Chinese Journal of Clinical Pharmacology

基　　金：中国博士后科学基金资助项目(2024M760449)。

摘　　要：肝纤维化是由各种慢性损伤和代谢紊乱引起的。肝硬化是进行性肝纤维化的终末期,估计影响全球1%~2%的人口,每年导致全球超过100万人死亡。肝星状细胞(HSCs)激活及维持活化是肝纤维化的主要驱动因素。同时,HSCs转分化过程中涉及到能量代谢重编程,是细胞生长所必需的一个关键代谢特征。目前的研究发现,Sirtuins蛋白家族在肝纤维化的进展中起着重要作用,尤其是对HSCs活化和能量代谢方面具有调控作用。能量代谢重编程涉及到多种细胞,包括肝细胞、HSCs以及免疫细胞等,通过靶向细胞内代谢限制纤维化进展是目前的研究热点。本文对Sirtuin蛋白家族在HSCs中能量代谢的调控作用进行综述。Liver fibrosis is caused by various chronic injuries and metabolic disorders.Cirrhosis is the end stage of progressive liver fibrosis,which is estimated to affect 1%-2%of the global population and cause more than 1 million deaths worldwide every year.Activation and maintenance of hepatic stellate cells(HSCs)are the main driving factors in liver fibrosis.At the same time,the process of trans-differentiation of HSCs involves reprogramming of energy metabolism,which is a key metabolic feature necessary to promote cell growth.Current studies found that Sirtuin protein family plays an important role in the progress of liver fibrosis,and further found that in the progress of liver fibrosis,especially after HSCs activation.Energy metabolism reprogramming involves various cells,including liver cells,HSCs,and immune cells.Targeting intracellular metabolism to limit fibrosis progression is currently a research hotspot.This article reviews the regulatory role of the Sirtuin protein family in energy metabolism in HSCs.

关 键 词：肝纤维化 肝星状细胞 沉默信息调节蛋白 代谢重编程 

分 类 号：R97[医药卫生—药品]