复合益生菌对老年重度抑郁症患者的疗效  

Clinical efficacy of compound probiotics in the treatment of senile patients with major depression

作　　者：王茜[1] 张莉 佟洋 徐晓峰 WANG Qian;ZHANG Li;TONG Yang;XU Xiaofeng(Shanghai Normal University Applied Psychology,Tianhua College,Shanghai 201815,China;不详)

机构地区：[1]上海师范大学天华学院,上海201815 [2]中国人民解放军96604部队医院 [3]空军杭州特勤疗养中心疗养二区

出　　处：《中国微生态学杂志》2025年第3期323-330,共8页Chinese Journal of Microecology

基　　金：上海市民办高校“民师计划”2022年管理人员类项目;2024年度上海市高等教育学会重点规划课题(2QZD2410)。

摘　　要：目的 从菌群、代谢和免疫的角度评价一款益生菌对老年重度抑郁症患者的治疗效果,为益生菌治疗抑郁症提供参考。方法 选取2020年6月至2023年6月我院收治的105例伴随焦虑症的老年重度抑郁症患者为研究对象,患者年龄均在65岁以上,随机分为对照组(n=52)和干预组(n=53)进行1个月的干预治疗,结束后检测身心指标、肠道菌群、代谢产物以及血清肿瘤坏死因子-α(TNF-α)、5-羟色胺(5-HT)水平。结果 治疗1个月后干预组患者的TNF-α水平为(12.81±7.16)pg/mL,显著低于对照组的(19.20±6.31)pg/mL,差异有统计学意义(P<0.05);干预组5-HT为(196.73±53.19)ng/mL,高于对照组的(151.89±87.52)ng/mL,差异有统计学意义(P<0.05)。干预组汉密尔顿抑郁症量表(HAMDS)评分总体水平降为(20.79±7.86)分,蒙哥马利-阿斯伯格抑郁评分量表(MADRS)的评分为(29.47±8.57)分,均显著低于对照组(均P<0.05)。干预组患者粪便中乙酸、丙酸和丁酸含量显著提高,同时干预组患者肠道长双歧杆菌长亚种数量显著升高(均P<0.05)。结论 益生菌可以通过改善菌群、调节代谢、降低炎症等多个途径改善抑郁症的治疗效果。Objective To evaluate the efficacy of probiotics in the treatment of elderly patients with major depressive disorder from the perspectives of microflora,metabolism and immunity,and provide a reference for the treatment.Methods A total of 105 geriatric depression patients with anxiety distress admitted to our hospital from June 2020 to June 2023,aged over 65 years old,were randomly divided into control group(n=52) and intervention group(n=53) for 1-month intervention treatment.After the intervention,the changes in physical and mental indexes,intestinal flora,metabolites and immune inflammation levels were detected.Results After 1 month of treatment,the level of TNF-α in the intervention group was(12.81±7.16) pg/mL,lower than that in the control group [(19.20±6.31) pg/mL].The 5-HT in the intervention group was(196.73±53.19) ng/mL,significantly higher than that in the control group [(151.89±87.52) ng/mL].HAMDS score decreased to 20.79±7.86 and MADRS score was 29.47±8.57 in the intervention group,which were significantly lower than those in the control group respectively(all P<0.05).The contents of fecal acetic acid,propionic acid and butyric acid in the intervention group significantly increased(all P<0.05).The amount of intestinal Bifidobacterium longum subsp.longum also increased significantly in the intervention group.Conclusion Probiotics can improve the therapeutic effect of depression by improving microflora,regulating metabolism and reducing inflammation.

关 键 词：益生菌 抑郁症 短链脂肪酸 炎症因子 

分 类 号：R451[医药卫生—治疗学]