基于肠-脑轴调控食欲探讨小儿厌食症发病机制  

Pathogenesis of pediatric anorexia based on the gut-brain axis regulating appetite

作　　者：何岳珍 李玉霞[3] 崔敏 刘青灵 陈静 史正刚 HE Yuezhen;LI Yuxia;CUI Min;LIU Qingling;CHEN Jing;SHI Zhenggang(Gansu University of Chinese Medicine,Lanzhou,Gansu 730000,China;不详)

机构地区：[1]甘肃中医药大学中医临床学院,甘肃兰州730000 [2]兰州大学第一医院中医科 [3]甘肃中医药大学附属医院儿科

出　　处：《中国微生态学杂志》2025年第3期345-349,共5页Chinese Journal of Microecology

基　　金：国家自然科学基金(81603660,82160921);甘肃省自然科学基金(22JR5RA572);兰州大学第一医院院内基金项目(ldyyyn2022-43)。

摘　　要：小儿厌食症是儿童时期常见的一种食欲障碍性疾病,严重威胁着儿童的生长发育和身心健康。肠-脑轴是由肠道菌群、胃肠道系统和中枢神经系统共同构成的双向信息交流通路。肠道菌群代谢产物、脑-肠肽及神经递质等信号分子作为肠脑双向应答的重要媒介,通过神经、免疫、内分泌和代谢途径作用于大脑食欲中枢,参与宿主食欲的调节,影响摄食行为,在小儿厌食症发生发展中发挥重要作用。本文综述了肠-脑轴介导宿主食欲调节导致厌食的作用机制,阐述了肠-脑轴失调与小儿厌食症的相关性,以期为靶向肠道菌群防治小儿厌食症提供理论依据。Pediatric anorexia is a common appetite disorder disease in childhood,which poses a serious threat to children's growth and development,as well as their physical and mental health.The gut-brain axis is a two-way information exchange pathway composed of intestinal flora,gastrointestinal system and central nervous system.As important mediators for gut-brain information exchange,the signaling molecules such as intestinal flora metabolites,brain-gut peptides and neurotransmitters act on the appetite center in the brain through neurological,immune,endocrine and metabolic pathways,participate in host appetite regulation,affect feeding behavior,and play an important role in the occurrence and development of pediatric anorexia.This article reviews the mechanism of gut-brain axis mediating host appetite regulation leading to anorexia,expounds that gut-brain axis dysregulation is closely related to pediatric anorexia,which provides a theoretical basis for targeting intestinal flora to prevent and treat pediatric anorexia.

关 键 词：肠-脑轴 食欲调节 小儿厌食症 

分 类 号：R725.7[医药卫生—儿科]