中药皂苷类成分纳米制剂的研究进展  

Research progress on the nano-preparation of traditional Chinese medicine saponins

作　　者：阮慧妮 丁文雅 杨旭 邹灵辉 李紫红 沈远乐 李凯童 王虹岚 王柳萍 奉建芳 RUAN Huini;DING Wenya;YANG Xu;ZOU Linghui;LI Zihong;SHEN Yuanle;LI Kaitong;WANG Honglan;WANG Liuping;FENG Jianfang(College of Pharmacy,Guangxi University of Chinese Medicine,Guangxi Nanning 530200,China;Key Laboratory of Common Technology Research and Development of Traditional Chinese Medicine Preparations in Guangxi Universities,Guangxi Nanning 530200,China;College of Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Guangxi Advantage Chinese Patent Medicine and National Medicine Development Engineering Technology Research Center,Guangxi Nanning 530200,China)

机构地区：[1]广西中医药大学药学院,广西南宁530200 [2]广西高校中药制剂共性技术研发重点实验室,广西南宁530200 [3]上海中医药大学中药学院,上海201203 [4]广西优势中成药与民族药开发工程技术研究中心,广西南宁530200

出　　处：《中国医院药学杂志》2025年第7期827-833,共7页Chinese Journal of Hospital Pharmacy

基　　金：国家自然科学基金项目(编号:82374044)。

摘　　要：皂苷类成分具有抗癌、抗炎和抗菌等药理作用,但因其注射给药产生的不良反应较多及口服生物利用度低而限制其临床应用。目前通过脂质体、纳米粒、纳米乳和聚合物胶束等多种纳米制剂形式,可显著提高其主动靶向性、生物利用度及治疗效果。对此,该文探讨了皂苷类成分纳米制剂在新型药物制剂领域中的研究进展,并针对其面临的挑战提出相应的优化策略,以期为皂苷类成分纳米制剂的研发提供参考。Saponins have pharmacological effects,including the anti-cancer,anti-inflammatory and anti-bacterial properties,but their clinical application are limited by many adverse events caused by injections and low oral bioavailability.Currently,various forms of nano-preparations,such as liposomes,nanoparticles,nanoemulsions and polymer micelles,can significantly improve the active targeting,bioavailability and therapeutic effects.In this review,we discussed the research progress of saponins nanopreparations in the field of new pharmaceutical preparations,and corresponding optimization strategies for the challenges,thus providing references for the development of saponins nano-preparations.

关 键 词：皂苷类成分 纳米制剂 药理作用 生物利用度 优化策略 

分 类 号：R944[医药卫生—药剂学]