硫酸镁注射液致孕妇急性尿潴留1例  

Adverse event analysis of acute urinary retention in pregnant women induced by magnesium sulfate injections

作　　者：李佩[1] 周盈莹[2] LI Pei;ZHOU Yingying(Department of Pharmacy,Huangshi Central Hospital,Hubei Huangshi 435000,China;Department of Pharmacy,Affiliated Hospital of Nantong University,Jiangsu Nantong 226001,China)

机构地区：[1]黄石市中心医院药学部,湖北黄石435000 [2]南通大学附属医院药学部,江苏南通226001

出　　处：《中国医院药学杂志》2025年第7期848-850,共3页Chinese Journal of Hospital Pharmacy

摘　　要：1例孕31^(+4)周妊娠期患者因“先兆早产,胎膜早破”入院。第1次静滴硫酸镁注射液,出现急性尿潴留,未停药,但予导尿术缓解不适;第2次静滴硫酸镁注射液,又出现急性尿潴留,停药后恢复;第3次静滴硫酸镁注射液再次发生急性尿潴留,依旧停药后恢复。该不良反应属新的不良反应,国内药品说明书尚未收载,可能与个体差异性和剂量等相关。硫酸镁注射液致尿潴留应作为病因学考虑的因素,建议加强硫酸镁注射液的安全监测及风险识别防控,促进临床安全用药。A pregnant women at the gestation age of 31^(+4)weeks was admitted due to threatened preterm delivery,and premature rupture of membranes.After the first dose of magnesium sulfate injection,the patient experienced acute urinary retention and relieved by catheterization.Magnesium sulfate injection was not discontinued,and after the second dose of magnesium sulfate injection,the patient experienced acute urinary retention again,but recovered after drug withdrawal.After the third dose of magnesium sulfate injection,the patient experienced acute urinary retention the third time,and recovered after drug withdrawal again.Acute urinary retention after magnesium sulfate injections in pregnant women is a newly identified adverse event,which has not been recorded in the domestic drug instructions and may be associated with individual difference and medication dosage.Urinary retention caused by magnesium sulfate injections should be considered as an influencing factor for the etiology.It is recommended to strengthen the safety monitoring,risk identification and prevention of magnesium sulfate to promote clinical safe medication.

关 键 词：硫酸镁注射液 尿潴留 孕妇 不良反应 

分 类 号：R282[医药卫生—中药学] R969[医药卫生—中医学]