超声介导的生物膜仿生纳米递送系统在疾病诊疗中的研究进展  

Research progress of ultrasound-mediated biomembrane biomimetic nanodelivery systems in disease diagnosis and treatment

作　　者：孟可欣 王蓓[1] MENG Kexin;WANG Bei(Ultrasound Medicine,the First Affiliated Hospital of Shandong First Medical University,Shandong Provincial Qianfoshan Hospital,Shandong Medical and Health Key Laboratory of Abdominal Medical Imaging,Ji’nan 250014,China;Shandong First Medical University,Shandong Academy of Medical Sciences,Ji’nan 250117,China)

机构地区：[1]山东第一医科大学第一附属医院山东省千佛山医院超声医学山东省医药卫生腹部医学影像学重点实验室,山东济南250014 [2]山东第一医科大学山东省医学科学院,山东济南250117

出　　处：《临床超声医学杂志》2025年第4期343-347,共5页Journal of Clinical Ultrasound in Medicine

基　　金：中国超声医师科技新星计划(KJXX2023006);济南市科技计划(202430018)。

摘　　要：无创、高效地治疗疾病已成为目前纳米医学研究的热点,细胞膜包衣技术已被证实能显著提升纳米递送系统的整体性能。传统纳米递送系统经细胞膜修饰后不仅能有效逃避免疫系统的清除,还能延长在血液循环中的停留时间,并精准抵达病变区域。将超声、细胞膜包衣技术与纳米递送系统相结合,可提高局部药物浓度、弥补传统声控递送系统的不足。本文就超声介导的生物膜仿生纳米递送系统在疾病诊断和治疗领域的最新研究进展进行综述,以期为未来纳米医学研究提供新的视角和启发。Non-invasive and high-efficiency disease treatment has become a research focus in nanomedicine,cell membrane coating technology has been demonstrated to significantly enhance the overall performance of nanodelivery systems.Traditional nanodelivery systems modified with cell membranes not only effectively evade immune clearancebut also prolong their circulation time in the bloodstream while achieving precise targeting of diseased regions.The integration of ultrasound with cell membrane coating technology and nanodelivery systems can enhance local drug concentration and address the limitations of conventional ultrasound-controlled delivery systems.This paper reviews the recent advances in ultrasound-mediated biomimetic membrane-base nanodelivery systems for disease diagnosis and therapeutic applications,aiming to provide novel perspectives and inspiration for future nanomedicine research.

关 键 词：超声分子影像 细胞膜 纳米递送 临床应用 

分 类 号：R445.1[医药卫生—影像医学与核医学]