基于代谢组学的中兽药抗炎作用机制研究进展  

Progress on the Anti-inflammatory Mechanisms of Traditional Chinese Veterinary Drugs Based on Metabolomics

作　　者：李晓蝶 潘诗琴 闵婷玉 王鲁[2] 程振涛[1,3,4] 欧德渊 宋旭琴[1,3,4] 杨剑 LI Xiao-die;PAN Shi-qin;MIN Ting-yu;WANG Lu;CHENG Zhen-tao;OU De-yuan;SONG Xu-qin;YANG Jian(Department of Veterinary Medicine,College of Animal Science,Guizhou University,Guiyang,Guizhou,550025,China;Engineering Research Center of Southwest Bio-pharmaceutical Resources,Ministry of Education,Guizhou University,Guiyang,Guizhou,550025,China;Guizhou Key Laboratory of Animal Epidemics and Veterinary Public Health,Guiyang,Guizhou,550025,China;Key Laboratory of Animal Genetics,Breeding and Reproduction in the Plateau Mountainous Region,Ministry of Education,Guizhou University,Guiyang,Guizhou,550025,China)

机构地区：[1]贵州大学动物科学学院动物医学系,贵州贵阳550025 [2]贵州大学教育部西南药用生物资源工程研究中心,贵州贵阳550025 [3]贵州省动物疫病与兽医公共卫生重点实验室,贵州贵阳550025 [4]贵州大学高原山地动物遗传育种与繁殖教育部重点实验室,贵州贵阳550025

出　　处：《动物医学进展》2025年第6期110-118,共9页Progress In Veterinary Medicine

基　　金：贵州省基础研究(自然科学)项目(黔科合基础-ZK[2022]一般129);国家自然科学基金项目(32202854);贵州省普通高等学校青年科技人才成长项目(黔教合KY字[2022]151号)。

摘　　要：代谢组学是继基因组学、转录组学和蛋白质组学之后的一门新兴学科。代谢组学对生物体特有的整体观、动态观与中医学理论的整体观不谋而合,故可作为一种用于发现疾病生物标志物及探索生命系统与药物之间复杂效应关系的有效工具。大量研究表明,中兽药对炎症反应有一定的抑制作用,但其抗炎机制有待进一步验证。基于代谢组学探讨中兽药药效机制,研究潜在生物标志物和治疗机制,更符合中兽医药的整体观。论文综述了基于代谢组学方法解决中兽药抗炎机制的具体实践,以期为代谢组学策略的中兽药研究发展方向进行展望。Metabolomics is a new branch of systematic biology after genomics,transcriptomics and proteomics.Metabonomics’s unique view of the whole and dynamic view of organism coincides with the holistic view of TCM theory,therefore,it can be used as an effective tool for finding disease biomarkers and exploring the complex effect relationship between life system and drugs.A large number of studies have shown that Chinese veterinary drugs have certain inhibitory effects on inflammatory reaction,but the anti-inflammatory mechanism needs further verification.Based on the metabolomics technology,the pharmacodynamic mechanism of Chinese veterinary drugs is discussed,and the potential biomarkers and therapeutic mechanisms are studied,more in line with the overall concept of Chinese medicine.This article reviews the practice of metabolomics-based approaches to the anti-inflammatory mechanism of traditional Chinese veterinary drugs,and looks forward to the future development of metabolomics.

关 键 词：代谢组学 中兽药 抗炎机制 

分 类 号：S853.74[农业科学—临床兽医学]