他非诺喹治疗动物巴贝斯虫病  

Tafenoquine in the Treatment of Babesiosis in Animals

作　　者：王奕博 汲生威 金春梅[1] WANG Yi-bo;JI Sheng-wei;JIN Chun-mei(College of Agriculture,Yanbian University,Yanji,Jilin,133002,China)

机构地区：[1]延边大学农学院,吉林延吉133002

出　　处：《动物医学进展》2025年第6期119-124,共6页Progress In Veterinary Medicine

基　　金：国家自然科学基金项目(32060807)。

摘　　要：巴贝斯虫病是一种蜱媒性寄生原虫病,由巴贝斯虫属寄生虫引起,主要通过受感染的蜱虫的叮咬来传播。巴贝斯虫病的症状包括高热、黄疸、溶血性贫血和血红蛋白尿等,严重时可导致病畜死亡。巴贝斯虫病的治疗通常使用抗原虫药物,如使用贝尼尔、地美沙明、三氮脒等药物进行肌肉注射或者采用青蒿素和强力霉素等抗菌药物进行口服,治疗的持续时间通常为7~10 d。他非诺喹是一种新型抗疟疾药物,同时也可用于巴贝斯虫病的治疗。他非诺喹药物的研究已经证明了其可以解决目前治疗巴贝斯虫病药物的耐药性问题,也证明了其良好的药物使用安全性。论文旨在总结巴贝斯虫病现今的治疗方案以及他非诺喹药物治疗巴贝斯虫病的研究进展,以期为更好地开展巴贝斯虫引起的疾病的预防和治疗提供参考。Babesiosis is a tick-borne protozoan malady instigated by parasites of the genus Babesia,predominantly transmitted through the hematophagous activity of infected ticks.Clinical manifestations of babesiosis encompass pyrexia,icterus,hemolytic anemia,and hemoglobinuria,with severe instances potentially culminating in mortality.The therapeutic regimen for babesiosis typically entails the administration of antiprotozoal drugs,such as imidocarb dipropionate,diminazen aceturate,and trypan blue via intramuscular injections,or oral antimicrobials including artemisinin and doxycycline.The prescribed treatment duration generally spans 7-10 days.Tafenoquine,an innovative antimalarial agent,has also demonstrated efficacy in treating babesiosis.Empirical studies on tafenoquine have elucidated its capacity to surmount extant issues of chemoresistance associated with babesiosis therapies,alongside confirming its favorable safety profile.This discourse endeavors to delineate the extant therapeutic strategies for babesiosis and the advancements in tafenoquine research,thereby furnishing a comprehensive reference for enhanced prophylaxis and management of Babesia-induced pathologies.

关 键 词：巴贝斯虫病 药物治疗 他非诺喹 

分 类 号：S852.746[农业科学—基础兽医学] S859.795[农业科学—兽医学]