儿童肺炎支原体肺炎凝血指标与炎症指标的相关性研究  

Study on the correlation between coagulation function and inflammatory indexes in children with Mycoplasma pneumoniae pneumonia

作　　者：杨丹 丁洁洁 车广华[2] YANG Dan;DING Jiejie;CHE Guanghua(Department of Pediatrics,Jilin Province FAW General Hospital,Changchun 130011,China;Department of Pediatrics,the Second Hospital of Jilin University,Changchun 130041,China)

机构地区：[1]吉林省一汽总医院儿科,吉林长春130011 [2]吉林大学第二医院儿科,吉林长春130041

出　　处：《中国实验诊断学》2025年第4期419-422,共4页Chinese Journal of Laboratory Diagnosis

基　　金：吉林省科技发展计划项目(20220401091YY)。

摘　　要：目的通过分析肺炎支原体肺炎(MPP)患儿外周血凝血指标、炎症指标及其二者相关性,探讨其对MPP病情判断的诊断价值。方法将确诊为MPP的住院患儿分为轻症组、重症组,抗感染治疗前采集患儿外周血行相关检测,分析其临床资料及检测结果。结果与轻症组比较,重症组患儿发热持续时间、剧咳时间和住院时间明显延长(P<0.05),重症组CRP、WBC、NE%、LDH及D-二聚体、纤维蛋白原水平升高(P<0.01),凝血酶原时间、活化部分凝血活酶时间延长,血小板计数显著下降(P<0.01)。重症组D-二聚体与外周血WBC、NE%、CRP及LDH均呈正相关(P<0.01)。结论MPP患儿外周血NE%、CRP、LDH等炎症指标及D-二聚体、FIB等凝血指标水平升高提示病情较重,临床可综合多种炎症及凝血指标综合判断MPP病情严重程度。Objective To explore the diagnostic value of peripheral blood coagulation indexes,inflammatory indexes and their correlation in children with Mycoplasma pneumoniae pneumonia(MPP).Methods Pediatric patients with MPP were divided into mild group and severe group.Peripheral serum titers of related indexes were detected before anti-infective treatment.Afterwards,clinical data and the above test results were analyzed.Results Compared with the indexes in the mild group,the duration of fever,severe cough time,and hospitalization time in the severe group were significantly longer(P<0.05).The level of CRP,WBC,NE%,D-dimer,fibrinogen(FIB)and LDH increased in the severe group(all P<0.01).The prothrombin time and activated partial thromboplastin time were prolonged,and the platelet count was significantly decreased,with all P<0.01.The level of D-dimer in severe MPP group was positively correlated with the level of WBC,NE%,CRP and LDH from peripheral blood,with all P<0.01.Conclusion The increased levels of inflammatory markers such as NE%,CRP,LDH,and coagulation markers such as D-dimer and FIB in the peripheral blood of children with MPP indicate a relatively severe condition.A comprehensive assessment of multiple inflammatory and coagulation markers can be used to judge the severity of the MPP.

关 键 词：肺炎支原体肺炎 儿童 凝血指标 炎症指标 重症 

分 类 号：R725.6[医药卫生—儿科]