间充质干细胞在骨科治疗中的应用与前景  

Application and prospect of mesenchymal stem cells in orthopedic treatment

作　　者：郭上 张书滔 施忠民[1] Guo Shang;Zhang Shutao;Shi Zhongmin(Foot and Ankle Section,Department of Orthopaedics,Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200233,China)

机构地区：[1]上海交通大学医学院附属第六人民医院骨科-足踝外科,上海200233

出　　处：《国际外科学杂志》2025年第3期145-150,共6页International Journal of Surgery

基　　金：上海市2024年度"科技创新行动计划"医学创新研究领域项目(24Y32800100)。

摘　　要：间充质干细胞(MSCs)是一种具有自我更新和多系分化潜能的多能干细胞,近年来MSCs作为一种治疗策略逐渐被应用于骨科疾病,如骨关节炎、类风湿关节炎、软骨损伤、腱骨损伤、骨缺损及退行性骨病,相较于无细胞疗法取得了更好的结果。但由于其来源广泛、作用机制复杂、产品种类丰富,骨科临床应用仍存在一定的局限性和争议。本文将探讨MSCs在骨科领域主要的应用现状及发展趋势,展望MSCs在骨科的应用前景。Mesenchymal stem cells(MSCs)are multipotent stem cells with the ability to self-renew and differentiate into multiple lineages.In recent years,MSCs have been increasingly used as a therapeutic strategy in orthopedic diseases such as osteoarthritis,rheumatoid arthritis,cartilage damage,tendon bone damage,bone defects,and degenerative bone diseases.Compared with cell-free therapy,MSCs have achieved better results.However,due to their widespread sources,complex action mechanisms,and diverse product types,there are certain limitations and controversies in their clinical application in orthopedics.This article will discuss the current main applications and future trends of MSCs in the field of orthopedics,looking forward to the prospects of MSCs application in orthopedics.

关 键 词：间质干细胞 腱损伤 骨再生 

分 类 号：R68[医药卫生—骨科学]