发热伴血小板减少综合征病毒的流行病学与致病机制研究进展  

Research progress on the epidemiology and pathogenesis of severe fever with thrombocytopenia syndrome virus

作　　者：李旦 于学杰 周传敏 LI Dan;YU Xue-jie;ZHOU Chuan-min(Hubei Provincial Center for Disease Control and Prevention,Institute for Infectious Disease Prevention and Control,Wuhan,Hubei 430079,China;不详)

机构地区：[1]湖北省疾病预防控制中心传染病防治所,湖北武汉430079 [2]病毒学国家重点实验室,武汉大学公共卫生学院 [3]武汉科技大学职业危害识别与控制湖北省重点实验室 [4]河北医科大学第一医院,胃肠病诊疗中心

出　　处：《现代预防医学》2025年第6期961-966,976,共7页Modern Preventive Medicine

基　　金：湖北省自然科学基金(2024AFB1046);国家自然科学基金(32470155,82302523);河北省自然科学基金优秀青年科学基金(H2023206290);病毒学国家重点实验室基金(2024KF002);职业危害识别与控制湖北省重点实验室基金(OHIC2023G07)。

摘　　要：发热伴血小板减少综合征病毒(SFTSV)是一种高致病性的蜱传布尼亚病毒,能够引发严重的病毒性出血热,发热伴血小板减少综合征(SFTS),其病死率最高可达30%。SFTSV于2010年首次被发现,主要通过蜱叮咬传播,亦可经病人或染病的猫犬等传播给人。SFTS主要临床表现包括高热、胃肠道以及血小板和白细胞减少等症状,部分重症患者因多脏器损害可能导致死亡。2017年,世界卫生组织宣布将SFTS列入有可能产生国际公共卫生紧急事件的优先级别疾病清单。同时,SFTS在中国及东亚、东南亚等地区均有报告病例,已成为重要的公共卫生问题;中国已有河南、湖北、山东、安徽、辽宁、浙江和江苏等27个省份报告了SFTS病例;韩国、日本、越南、缅甸、泰国和巴基斯坦等东亚及东南亚国家也已发现SFTS病例。为此,本文围绕SFTSV流行病学与致病机制作一综述,为加深理解免疫逃逸致病机制和研发应对技术提供依据。Severe fever with thrombocytopenia syndrome virus(SFTSV)is a highly pathogenic tick-borne bunyavirus that can cause severe viral hemorrhagic fever(SFTS),with a case fatality rate of up to 30%.SFTSV was first identified in 2010,which is primarily transmitted through tick bites but can also be transmitted to humans by sick people or infected cats and dogs.The main clinical manifestations of SFTS include high fever,gastrointestinal symptoms,thrombocytopenia,and leukopenia,with severe cases potentially resulting in death due to multi-organ failure.In 2017,the World Health Organization(WHO)listed SFTS as a priority disease with the potential to cause a public health emergency of international concern.SFTS cases have been reported in China,East Asia,and Southeast Asia,making it an important public health issue.In China,SFTS cases have been reported in 27 provincesincluding Henan,Hubei,Shandong,Anhui,Liaoning,Zhejiang,and Jiangsu.Additionally,SFTS cases have been identified in East and Southeast Asian countries such as South Korea,Japan,Vietnam,Myanmar,Thailand,and Pakistan.This review summarizes the epidemiology and pathogenesis of SFTSV,providing a basis for better understanding the mechanisms of immune evasion and developing effective countermeasures.

关 键 词：发热伴血小板减少综合征病毒 流行病 免疫逃逸 致病机制 

分 类 号：R373.3[医药卫生—病原生物学]