N,N-二乙基-2-(甲氨氧基)乙胺盐酸盐的合成  

Synthesis of N,N -diethyl-2-((methylamino)oxy)ethanamine Hydrochloride

作　　者：黄旭虎 HUANG Xuhu(HTA Co.,Ltd.,Beijing 102413,China)

机构地区：[1]原子高科股份有限公司,北京102413

出　　处：《山东化工》2025年第7期43-45,共3页Shandong Chemical Industry

摘　　要：以二苯甲酮肟和N,N-二乙基-2-氯乙胺盐酸盐为原料,通过五步反应合成了N,N-二乙基-2-(甲氨氧基)乙胺盐酸盐,分别是O-烷基化反应、水解反应、氨基Boc保护、甲基化、脱Boc保护,反应的总收率为25%。研究了关键中间体2-(氨氧基)-N,N-二乙基乙胺二盐酸盐的制备条件,并且用^(1)H-NMR和^(13)C-NMR对所有中间体和目标产物N,N-二乙基-2-(甲氨氧基)-乙胺盐酸盐的结构进行了鉴定。Using benzophenone oxime and 2-diethylaminoethyl chloride hydrochloride as starting material,N,N-diethyl-2-((methylamino)oxy)ethanamine hydrochloride was synthesized from via five steps,including substitution reaction,hydrolysis reaction,Boc protection,methylation and Boc deprotection.The total product yield was 25%.And the structure of N,N-diethyl-2-((methylamino)oxy)ethanamine hydrochloride was confirmed by^(1)H-NMR and ^(13)C-NMR.

关 键 词：N N-二乙基-2-(甲氨氧基)乙胺盐酸盐 合成 结构表征 

分 类 号：TQ463[化学工程—制药化工]