一次性使用输液器带针与4种临床输液药物的相容性研究  

Study on the Compatibility of Disposable Infusion Sets with Needles andFour Clinical Infusion Drugs

作　　者：孙永康 李妍汝 隋玉杰 赵昌军 SUN Yongkang;LI Yanru;SUI Yujie;ZHAO Changjun(Zibo Institute for Food and Drug Control,Zibo 255086,China;School of Pharmaceutical Sciences and Food Engineering,Liaocheng University,Liaocheng 252000,China;Shouguang General Hospital,Weifang 261000,China)

机构地区：[1]淄博市食品药品检验研究院,山东淄博255086 [2]聊城大学药品与食品工程学院,山东聊城252000 [3]寿光综合医院,山东潍坊261000

出　　处：《山东化工》2025年第7期55-59,共5页Shandong Chemical Industry

基　　金：2023年淄博市科技型中小企业创新能力提升工程计划(项目编号:2023tsgc0028)。

摘　　要：目的:旨在深入探讨一次性使用输液器带针与4种临床常用输液药物在输液过程中的相容性。方法:通过一系列严格设计的实验,分别考察了输液器对药物溶液稳定性的影响,以及药物溶液对输液器中化学物质溶出的作用。实验中,对药物溶液的鉴别、有关物质和药物含量等指标进行了持续监测,并运用高效液相分析技术对输液器中可能溶出的化学物质进行了精准鉴定和定量分析。结论:该一次性使用输液器带针与所选择的4种临床输液药物的相容性良好。Objective:This study aims to explore in depth the compatibility of disposable infusion sets with needles and four commonly used clinical infusion drugs during the infusion process.Method:Through a series of rigorously designed experiments,the influence of infusion sets on the stability of drug solutions and the effect of drug solutions on the dissolution of chemical substances in infusion sets were investigated.In the experiment,continuous monitoring was conducted on the identification of drug solutions,related substances,and drug content indicators.High performance liquid chromatography analysis technology was used to accurately identify and quantitatively analyze chemical substances that may dissolve in the infusion set.Conclusion:The disposable infusion set with needle has good compatibility with the four selected chemical infusion drugs.

关 键 词：输液器带针 溶液稳定性 溶出 相容性 鉴别 有关物质 含量 

分 类 号：TQ460[化学工程—制药化工] O657.7[理学—分析化学]