白血病患儿癌症相关认知障碍前哨因子及其评估工具研究进展  

Research advances in sentinel factors for cancer-related cognitive impairment and related assessment tools in children with leukemia

作　　者：曾燕 莫霖[2] 陈泽方 刘涛 Zeng Yan;Mo Lin;Chen Zefang;Liu Tao(Chongqing Medical University School of Nursing/Department of Nursing,Children's Hospital of Chongqing Medical University;National Clinical Research Center for Child Health and Disorders/Ministry of Education Key Laboratory of Child Development and Disorders,Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders/Outpatient Department, Children's Hospital of Chongqing Medical University)

机构地区：[1]重庆医科大学护理学院/附属儿童医院护理部,重庆400014 [2]重庆医科大学国家儿童健康与疾病临床医学研究中心/儿童发育疾病研究教育部重点实验室/儿童神经发育与认知障碍重庆市重点实验室/附属儿童医院门诊部,重庆400014

出　　处：《重庆医科大学学报》2025年第4期482-487,共6页Journal of Chongqing Medical University

基　　金：国家自然科学基金面上资助项目(编号:72474040)。

摘　　要：癌症相关认知障碍是白血病患儿常见且严重的并发症,影响患儿远期生存质量,并对其学业、生活及社交产生不良影响。通过文献综述,本文总结出癌症相关认知障碍前哨因子包括失眠、焦虑、抑郁、大剂量甲氨蝶呤暴露、脑脊液中溶血磷脂酰胆碱水平降低,鞘磷脂浓度升高、MTHFR1298基因型以及肿瘤坏死因子α、白介素6、白介素8升高。目前有关前哨因子的评估工具缺乏敏感性及特异性,建议后续开展大样本、多中心研究验证以上指标对白血病患儿癌症相关认知障碍的精准预测性,实现早期干预,以提高患儿远期生存质量。Cancer-related cognitive impairment is a common and serious complication in children with leukemia,which affects the quality of long-term survival and has adverse impact on their schooling,life,and socialization.Through a literature review,this article summarizes the sentinel factors for cancer-related cognitive impairment,including insomnia,anxiety,depression,high-dose methotrexate exposure,decreased lysophosphatidylcholine levels and elevated sphingomyelin concentrations in cerebrospinal fluid,MTHFR 1298 genotype,and increases in inflammatory factors(TNF-α,IL-6,and IL-8).The existing assessment tools for sentinel factors lack sensitivity and specificity,and subsequent large-sample multicenter studies should be conducted to validate the accuracy of the above indicators in predicting cancer-related cognitive impairment in children with leukemia,so as to achieve early intervention and improve the quality of long-term survival.

关 键 词：白血病 认知障碍 癌症 儿童 

分 类 号：R47[医药卫生—护理学]