高同型半胱氨酸血症与慢性肾脏病关系的研究进展  

Research Progress in the Relationship Between Hyperhomocysteinemia and Chronic Kidney Disease

作　　者：丁聪聪 黄晓[1,2,3,4] 鲍慧慧 程晓曙[1,2,3,4] DING Congcong;HUANG Xiao;BAO Huihui;CHENG Xiaoshu(Department of Cardiovascular Medicine,The Second Affiliated Hospital of Nanchang University,Nanchang 330006,China;Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center,Nanchang 330006,China;Jiangxi Sub-Center of National Clinical Research Center for Cardiovascular Diseases,Nanchang 330006,China;Center for Prevention and Treatment of Cardiovascular Diseases,The Second Affiliated Hospital of Nanchang University,Nanchang 330006,China)

机构地区：[1]南昌大学第二附属医院心血管内科,南昌330006 [2]江西省心血管疾病临床医学研究中心,南昌330006 [3]国家心血管疾病临床医学研究中心分中心,南昌330006 [4]南昌大学第二附属医院心血管病防治中心,南昌330006

出　　处：《中国医学科学院学报》2025年第2期281-288,共8页Acta Academiae Medicinae Sinicae

基　　金：国家科技奖后备项目培育(20223AEI91007);江西省科技创新基地计划-江西省临床医学研究中心(20223BCG74012);江西省科技创新基地建设项目(20221ZDG02010);南昌大学第二附属医院基金(2021efyA01)。

摘　　要：在慢性肾脏病(CKD)患者中,心血管事件和死亡率显著高于普通人群。约85%的终末期CKD患者因肾功能受损而出现高同型半胱氨酸血症(HHcy)。目前,尚未完全确定HHcy是仅作为CKD的生物标志还是参与其致病过程。尽管补充叶酸和其他B族维生素(B6与B12)被证实可以降低血浆总同型半胱氨酸水平,但其对于延缓CKD进展或减少心血管并发症的有效性仍有待确定。本文主要综述HHcy与CKD关系的最新研究进展,旨在为CKD及其并发症的预防和治疗提供新的见解。In patients with chronic kidney disease(CKD),the incidence of cardiovascular events and the mortality rate are significantly higher than those in the general population.Approximately 85%of end-stage CKD patients develop hyperhomocysteinemia(HHcy)due to impaired renal function.It is not yet fully determined whether HHcy merely acts as a biomarker of CKD or plays a role in the pathogenesis.Although supplementation with folic acid and other B vitamins(B6 and B12)has been proven to lower the plasma level of total homocysteine,their effectiveness in slowing CKD progression or reducing cardiovascular complications remains uncertain.This article reviews the latest research progress in the relationship between HHcy and CKD,aiming to give new insights into the prevention and treatment of CKD and its complications.

关 键 词：慢性肾脏病 同型半胱氨酸 高同型半胱氨酸血症 叶酸 维生素 

分 类 号：R589[医药卫生—内分泌]