P糖蛋白在不同组织器官中的定位和调控研究进展  

Advances in the Localization and Regulation of P-glycoprotein in Different Tissues and Organs

作　　者：赵家华 杨小飒 许晓娇 刘睿 庄田田 张家堂 ZHAO Jiahua;YANG Xiaosa;XU Xiaojiao;LIU Rui;ZHUANG Tiantian;ZHANG Jiatang(School of Medicine,Nankai University,Tianjin 300071,China;Department of Neurology,The First Medical Center,Chinese PLA General Hospital,Beijing 100853,China;Graduate School,Medical School of Chinese PLA,Beijing 100853,China)

机构地区：[1]南开大学医学院,天津300071 [2]中国人民解放军总医院第一医学中心神经内科医学部,北京100853 [3]解放军医学院研究生院,北京100853

出　　处：《中国医学科学院学报》2025年第2期295-302,共8页Acta Academiae Medicinae Sinicae

摘　　要：P糖蛋白(P-gp)是一种ATP依赖的外排转运体,在许多组织器官中均有分布。P-gp可以选择性地将内源性底物和外源性化学物质由细胞内泵入细胞外,维持内环境稳定,但同时也限制了治疗性药物进入组织器官,尤其是介导了肿瘤细胞对化疗药物的多药耐药。因此,了解P-gp在不同组织器官中的定位,可能是疾病治疗的重要突破点。本文主要综述P-gp的分子结构、转运机制、不同组织器官的定位和调控等,为后续疾病的治疗提供参考。P-glycoprotein(P-gp)is an ATP-dependent efflux transporter that is distributed in many tissues and organs.P-gp can selectively pump endogenous substrates and exogenous chemicals from the cell to the outside of the cell to maintain a stable endo-environment.However,it meanwhile restricts the entry of therapeutic drug into tissues and organs,and in particular,mediates the multidrug resistance of tumor cells to chemotherapeutic drugs.Therefore,understanding the localization of P-gp in different tissues and organs may be an important breakthrough point for disease treatment.In this paper,we mainly review the molecular structure,transport mechanism,localization,and regulation of P-gp in different tissues and organs,providing reference for the subsequent treatment of diseases.

关 键 词：P糖蛋白 分子结构 转运机制 定位 调控 

分 类 号：Q71[生物学—分子生物学]