自主神经调节策略在心肌梗死治疗中的研究进展  

Research Progress of Autonomic Nerve Regulation in the Treatment of Myocardial Infarction

作　　者：李珊珊 熊梦婷 郭苗苗 LI Shanshan;XIONG Mengting;GUO Miaomiao(Cardiac Function Examination Room,Jingmen People’s Hospital,Central Hospital Affiliated to Jingchu University of Technology,Jingmen,Hubei 448000,China;Department of Pharmacy,Jingmen People’s Hospital,Central Hospital Affiliated to Jingchu University of Technology,Jingmen,Hubei 448000,China)

机构地区：[1]荆门市人民医院、荆楚理工学院附属中心医院心功能室,湖北荆门448000 [2]荆门市人民医院、荆楚理工学院附属中心医院药学部,湖北荆门448000

出　　处：《中国医学科学院学报》2025年第2期309-313,共5页Acta Academiae Medicinae Sinicae

摘　　要：由交感神经过度激活以及副交感神经活性减弱导致的自主神经系统失衡与心肌梗死的发生发展密切相关。自主神经调节技术是一种以抑制交感神经张力、增加副交感神经张力为目标的新型干预手段,包括神经磁刺激、光遗传神经调控以及神经毒素微注射调控等技术,可促进自主神经再平衡,从而有效改善心肌梗死后心功能恶化,减少室性心律失常的发生。本文主要综述自主神经的解剖基础、作用机制及相关调控技术在心肌梗死中的研究进展。The autonomic nervous system imbalance caused by the overactivation of the sympathetic nerve and the weakened activity of the parasympathetic nerve is closely related to the occurrence and development of myocardial infarction.Autonomic nerve regulation is a new therapeutic approach aiming at inhibiting sympathetic activity and increasing parasympathetic activity.It encompasses magnetic nerve stimulation,optogenetic neuromodulation,and microinjection of botulinum toxin,which could promote the rebalance of the autonomic nervous system,thereby curbing the deterioration of the cardiac function and reducing the occurrence of ventricular arrhythmias after myocardial infarction.This paper reviews the anatomical basis,mechanisms of action,and research advances in intervention strategies of the autonomic nervous system in myocardial infarction.

关 键 词：自主神经 心肌梗死 室性心律失常 迷走神经 

分 类 号：R541[医药卫生—心血管疾病]