自拟通络软肝汤加减对乙肝肝硬化失代偿期患者肝纤维化及T细胞亚群的影响  

Effects of tongluo ruangan decoction on liver fibrosis and T cell subsets in patients with decompensated hepatitis B cirrhosis

作　　者：郭亚南 陈飞朋 GUO Yanan;CHEN Feipeng(The Sixth People's Hospital of Zhengzhou,Zhengzhou 450000,China;Jinshui District General Hospital,Zhengzhou 450000,China)

机构地区：[1]郑州市第六人民医院,河南郑州450000 [2]郑州市金水区总医院,河南郑州450000

出　　处：《临床医药实践》2025年第5期338-342,共5页Proceeding of Clinical Medicine

摘　　要：目的:分析自拟通络软肝汤加减对乙肝肝硬化失代偿期患者肝纤维化及T细胞亚群的影响。方法:选取2021年10月-2023年10月郑州市第六人民医院收治的乙肝肝硬化失代偿期患者82例为研究对象,随机分为对照组和观察组,每组41例。对照组口服恩替卡韦分散片,观察组在对照组基础上增加自拟通络软肝汤加减治疗。比较两组患者临床疗效、中医症状评分、肝纤维化、T细胞亚群及不良反应。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);治疗3个月后,两组中医症状评分及肝纤维化水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗3个月后,两组CD3^(+),CD4^(+),CD4^(+)/CD8^(+)水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗3个月后,两组CD8^(+)低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:自拟通络软肝汤加减对乙肝肝硬化失代偿期患者的治疗效果显著,能有效减轻患者的临床症状和肝纤维化程度,有利于机体细胞免疫功能的提升。Objective:To analyze the effects of tongluo ruangan decoction on liver fibrosis and T cell subsets in patients with decompensated hepatitis B cirrhosis.Methods:All 82 cases of patients with decompensated hepatitis B cirrhosis in hospital from October 2021 to October 2023 were selected as the study objects,41 cases in the control group were treated with conventional Western medicine,and 41 cases in the observation group were treated with self-prepared Tongluangan decoction.Clinical efficacy,traditional Chinese medicine symptom score,liver fibrosis,T cell subsets and adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was higher than the control group(P<0.05).After 3 months of treatment,the scores of TCM symptoms and the level of hepatic fibrosis in the two groups were lower than those before treatment,and the observation group was lower than that in the control group,with statistical significance(P<0.05).After 3 months of treatment,the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in both groups were higher than those before treatment,and the difference was statistically significant(P<0.05).CD8^(+)in the two groups was lower than that before treatment,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Tongluo ruangan decoction can effectively reduce the clinical symptoms and degree of liver fibrosis in patients with decompensated hepatitis B cirrhosis,and is conducive to the improvement of cellular immune function.

关 键 词：自拟通络软肝汤 乙肝肝硬化 失代偿期 肝纤维化 T细胞亚群 

分 类 号：R285.5[医药卫生—中药学]