单胺氧化酶和5'-核苷酸酶及腺苷脱氨酶水平在肝癌患者中的表达及诊断价值分析  

Expression and diagnostic value of monoamine oxidase,5' -nucleotidase and adenosine deaminase in patients with livercancer

作　　者：周晓光[1] 杨俊[1] 何文芳 丁美芳 ZHOU Xiaoguang;YANG Jun;HE Wenfang;DING Meifang(Fengcheng Hospital of Traditional Chinese Medicine Laboratory,Fengcheng 331100,China;Fengcheng Maternal and Child Health Hospital,Fengcheng 331100,China)

机构地区：[1]丰城市中医院,江西丰城331100 [2]丰城市妇幼保健院,江西丰城331100

出　　处：《临床医药实践》2025年第5期367-370,共4页Proceeding of Clinical Medicine

摘　　要：目的:分析单胺氧化酶(MAO)、5'-核苷酸酶(5'-NT)、腺苷脱氨酶(ADA)在肝癌患者中的诊断价值。方法:选取2022年7月-2023年7月丰城市中医院收治的50例肝癌患者(肝癌组)和在医院同期进行治疗的50例良性肝病患者(良性肝病组),另外纳入自愿参与研究的健康者50例作为健康组。对所有受检者的MAO,5'-NT,ADA水平进行检测,统计对比各组MAO,5'-NT,ADA水平,采用受试者工作特征曲线(ROC)评估各项指标(MAO,5'-NT,ADA)单独检测及联合检测的诊断效能,对比不同病情肝癌患者上述指标的差异。结果:肝癌组MAO,5'-NT及ADA水平高于其他组,良性肝病组高于健康组(P<0.05);ROC曲线分析结果显示,MAO,5'-NT,ADA单独检测及联合诊断的AUC分别为0.711,0.621,0.694和0.804,提示联合检测的诊断价值较高,组间比较差异有统计学意义(P<0.05);肝癌组Ⅲ期亚组患者上述指标高于Ⅰ~Ⅱ期亚组,差异有统计学意义(P<0.05)。结论:MAO,5'-NT及ADA水平越高,表明肝癌患者病情程度越严重,临床上可通过上述指标的水平变化对肝癌病情进行诊断、评估,且各项指标联合检测可提高疾病诊断的效能,为后续治疗及预后恢复提供更多依据。Objective:To analyze the diagnostic value of monoamine oxidase(MAO),5'-nucleotidase(5'-NT),and adenosine deaminase(ADA)levels in patients with liver cancer.Methods:From July,2022 to July,2023,50 patients with liver cancer(liver cancer group)and 50 patients with benign liver disease(benign liver disease group)who were treated in fengcheng city Hospital of Traditional Chinese Medicine were selected.Additionally,50 healthy volunteers were included as a control group.The levels of MAO,5'-NT,and ADA were measured in all subjects,and the data were statistically compared among the groups.The diagnostic efficacy of each marker(MAO,5'-NT,ADA)alone and in combination was assessed using the receiver operating characteristic(ROC)curve.Compare the differences of the above indexes in patients with different conditions of liver cancer.Results:The levels of MAO,5'-NT and ADA in liver cancer group were higher than those in other groups,and those in benign liver disease group were higher than those in healthy group(P<0.05).ROC curve analysis showed that the AUC of MAO,5'-NT and ADA were 0.711,0.621,0.694 and 0.804,respectively,suggesting that the diagnostic value of combined detection was high,with significant differences between groups(P<0.05).The above indexes of patients with stageⅢliver cancer were higher than those of patients with stageⅠ-Ⅱliver cancer(P<0.05).Conclusion:Higher levels of MAO,5'-NT,and ADA suggest more severe liver cancer conditions.Clinically,these markers can be used to diagnose and assess the condition of liver cancer patients,and the combined detection of these markers can improve the diagnostic efficacy of the disease,providing more basis for subsequent treatment and prognosis.

关 键 词：单胺氧化酶 5'-核苷酸酶 腺苷脱氨酶 肝癌 诊断价值 

分 类 号：R259[医药卫生—中西医结合]