中国献血者人群丙氨酸氨基转移酶血液筛查策略调整专家共识  

Expert consensus on the adjustment of blood screening strategy for alanine aminotransferase in Chinese blood donors

作　　者：国家卫生健康委临床检验中心血液筛查专家组 王瑞[2] 王淏[3] 臧亮[4] 黄力勤 常乐[6] 何敏[7] 郑欣[5] 党英男 曾劲峰[5] 王露楠[6] 张传宝[6] 马洁 Blood Screening Expert Group,National Center for Clinical Laboratories

机构地区：[1]不详 [2]北京市红十字血液中心 [3]广州血液中心 [4]大连市血液中心 [5]深圳市血液中心 [6]北京医院国家卫生健康委临床检验中心 [7]吉林省血液中心 [8]青海省血液中心

出　　处：《中国输血杂志》2025年第4期455-464,共10页Chinese Journal of Blood Transfusion

基　　金：四大慢病重大专项(2024ZD0523703);深圳市医疗卫生三名工程(SZSM202311032)。

摘　　要：丙氨酸氨基转移酶(ALT)作为非特异性检测肝炎的替代试验,在20世纪90年代被我国将其列为献血者筛查的强制性检测项目并沿用至今。然而,ALT作为病毒感染的非特异性指标,其升高易受到多方面因素的影响,导致部分健康献血者因ALT暂时性升高而无法献血,造成了血液资源浪费。本专家共识基于既往研究结果和前期调研数据,聚焦于ALT筛查策略的优化,旨在为献血者血液ALT检测效果的验证、检测策略的调整以及ALT筛查中的实际操作提供全面且专业的指导。Alanine aminotransferase(ALT),as a non-specific alternative test for hepatitis detection,was listed as a mandatory screening item for blood donors in China in the 1990s and has been continued to this day.However,as a non-specific indicator of viral infection,the elevation of ALT is easily affected by various factors,resulting in some healthy blood donors being unable to donate blood due to a temporary increase in ALT levels,which leads to a waste of blood resources.Based on previous research findings and preliminary survey data,this expert consensus focuses on optimizing the ALT screening strategy,aiming to provide comprehensive and professional guidance for verifying the effectiveness of ALT testing in blood donors,adjusting the testing strategy,and the practical operation in ALT screening.

关 键 词：丙氨酸氨基转移酶 筛查策略 合格标准 质量保证 

分 类 号：R457.1[医药卫生—治疗学] R446.6[医药卫生—临床医学]