丙氨酸氨基转移酶不合格重复献血者检测情况分析  

Analysis of detection of repeat blood donors with unqualified alanine aminotransferase

作　　者：曾梓建 廖芬芳 谢君谋[1] 万芷婷 杜荣松[1] 李仲平[1] 梁浩坚[1] 黎世杰[1] 姬艳丽[1] 梁华钦[1] 王淏[1] ZENG Zijian;LIAO Fenfang;XIE Junmou;WAN Zhiting;DU Rongsong;LI Zhongping;LIANG Haojian;LI Shijie;JI Yanli;LIANG Huaqin;WANG Hao(Guangzhou Blood Center,Institute of Blood Transfusion and Hematology,The Key Medical Laboratory of Guangzhou,Guangzhou 510095,China)

机构地区：[1]广州血液中心、广州医科大学输血与血液病研究所、广州市血液安全重点实验室,广东广州510095

出　　处：《中国输血杂志》2025年第4期482-487,共6页Chinese Journal of Blood Transfusion

基　　金：广州市科技计划项目(2024A03J0447,2025A03J3452);广东省医学科学技术研究基金项目(A2024391);广州市医学重点学科(2025-2027)。

摘　　要：目的回顾分析广州地区丙氨酸氨基转移酶(ALT)不合格重复献血者检测结果,为进一步扩大重复献血者队伍,降低血液报废率和提高血液检验合格率提供依据。方法选取广州血液中心2018年1月—2024年4月ALT不合格的献血者为研究对象,根据其献血次数和ALT不合格次数分析过往献血情况和人群特征。结果重复献血者过往ALT不合格中99.5%~99.7%不合并输血传播疾病(TTD)标志物反应性,该比率高于初次献血ALT不合格献血者(95.8%)(P<0.05)。重复献血者出现单项ALT不合格的比率,男性高于女性(P<0.05);年龄18~25岁>26~35岁>36~45岁>45岁以上(P<0.05);第3、4季度>第1、2季度(P<0.05);献全血的比率明显高于献血小板和归队献血者(P<0.05)。多次ALT不合格的重复献血者ALT总体水平(51.0 U/L)、个人ALT平均水平(56.0 U/L)和个人ALT不合格率(66.7%)均高于单次ALT不合格的重复献血者(26.0 U/L、38.5 U/L、33.3%)(P<0.05),且随着ALT不合格次数的增加,重复献血者ALT总体水平升高(P<0.05),个人ALT平均水平和个人ALT不合格率有升高的趋势;高频次ALT不合格献血者ALT处于较高水平(69.0 U/L)。结论重复献血者ALT不合格多数为不合并TTD的非特异性升高,多次ALT不合格的献血者存在ALT持续偏高的特征,且随着ALT不合格次数越多,其ALT总体水平、个人ALT平均水平和个人ALT不合格率呈升高趋势。Objective To retrospectively analyze the detection results of alanine aminotransferase(ALT)unqualified repeat blood donors in Guangzhou,so as to provide evidence for further expanding the repeat blood donor pool,reducing the rate of blood discarding and improving the qualified rate of blood test.Methods Blood donors with unqualified ALT in Guangzhou Blood Center from January 2018 to April 2024 were selected as the research objects.The past blood donation and population characteristics were analyzed according to the number of blood donations and ALT unqualified times.Results Among repeat blood donors with previous ALT disqualification,99.5%to 99.7%did not have reactive markers for transfusion-transmitted diseases(TTD),which was higher than the rate among first-time blood donors with unqualified ALT(95.8%)(P<0.05).The rate of single-item ALT disqualification in repeat blood donors was higher in males than in females(P<0.05);it also varied by age(18-25 years>26-35 years>36-45 years>over 45 years)(P<0.05);and by quarter(third and fourth quarters>first and second quarters)(P<0.05).The ALT unqualified rate was significantly higher whole blood donors than that of platelet donors and returning blood donors(P<0.05).The overall ALT level(51.0 U/L),individual ALT level(56.0 U/L)and individual ALT unqualified rate(66.7%)of repeat blood donors with multiple ALT disqualifications were higher than those of repeat blood donors with single-item ALT disqualifications(26.0 U/L,38.5 U/L,and 33.3%,respectively)(P<0.05).Moreover,as the number of ALT disqualifications increased,the overall level of ALT in repeat blood donors also increased(P<0.05),and the average level of individual ALT and individual ALT unqualified ratio tended to increase.Repeat blood donors with frequent ALT disqualifications had higher ALT levels(69.0 U/L).Conclusion The ALT unqualified rates of repeat blood donors were mostly non-specific elevation without TTD.Repeat blood donors with multiple ALT disqualifications tend to have continuous high ALT.Moreover,and wi

关 键 词：重复献血者 血液检测 ALT 

分 类 号：R457.1[医药卫生—治疗学] R446.6[医药卫生—临床医学]