采供血机构常态化冰冻红细胞库的构建  

Establishment of regularized cryopreserved red blood cell banks in blood collection and supply institutions

作　　者：林华雨 庄远 于洋 LIN Huayu;ZHUANG Yuan;YU Yang(The First Medical Center of the PLA General Hospital,Department of Blood Transfusion Medicine,Beijing 100853,China)

机构地区：[1]中国人民解放军总医院第一医学中心输血医学科,北京100853

出　　处：《中国输血杂志》2025年第4期508-513,共6页Chinese Journal of Blood Transfusion

摘　　要：血液资源短缺是我国公共卫生体系面临的一个严峻挑战,区域不平衡、季节性波动与过期报废问题共存。冰冻红细胞技术凭借超长保存期、良好的输注效果及安全性,有望成为缓解常态化血液短缺、优化资源配置的战略路径。本文系统梳理红细胞冰冻保存的技术演进,阐明其核心优势,并揭示其在规模化应用中的瓶颈与改进方向。构建常态化冰冻红细胞库具有多维战略价值,然而实践推广需破解解冻时效性、标准化建设及基层设备配置不足等矛盾。未来技术改进应聚焦非甘油免洗涤技术、解冻后延长保存添加液配方及智能化解冻设备研发,突破通量与时空限制,为构建常态化冰冻红细胞库提供更为有利的技术支撑,助力我国血液安全保障体系的高效发展。Blood resource shortages,characterized by regional imbalance,seasonal fluctuations,and expiration-related wastage,pose a critical challenge to China′s public health system.Cryopreserved red blood cell(RBC)technology,with its ultra-long preservation period,transfusion efficacy,and safety,offers a strategic pathway to alleviate chronic blood shortages and optimize resource allocation.This article systematically reviews the technological evolution of RBC cryopreservation,clarifies its core advantages,and identifies bottlenecks and improvement strategies in large-scale application.The establishment of a regularized cryopreserved RBC bank holds multidimensional strategic value;however,its practical implementation requires resolving challenges such as thawing timeliness,standardization gaps,and insufficient grassroots equipment.Future advancements should prioritize glycerol-free washing-free cryopreservation technologies,post-thaw extended preservation additive formulations,and intelligent thawing equipment to overcome throughput and spatiotemporal constraints,thereby providing robust technical support for building a regularized cryopreserved RBC bank and enhancing the efficiency of China’s blood security framework.

关 键 词：冰冻红细胞 常态化库构建 血液资源管理 

分 类 号：R457.1[医药卫生—治疗学]