Clinical Management of Acute Mastoiditis in a Pediatric Patient with Leukocyte Adhesion Deficiency  

作　　者：Allahverdi Aghayev Alparslan Gonul Hazan Basak 

机构地区：[1]Department of Otolaryngology,Ankara University,School of Medicine,Ankara,Turkey

出　　处：《Journal of Otology》2025年第2期127-132,共6页中华耳科学杂志(英文版)

摘　　要：Leukocyte adhesion deficiency type-1 is frequently associated with otorhinolaryngological manifestations,most notably a high prevalence of otitis media.Although multiple case reports have documented an increased prevalence of acute otitis media and mastoiditis in patients with LAD-1,no clinical or experimental studies have fully elucidated the pathophysiological mechanisms underlying this association.Despite guideline recommendations for urgent antibiotic therapy in immunocompromised patients with acute otitis media,a standardized treatment protocol for its complications remains lacking.Moreover,no established consensus exists regarding the optimal therapeutic approach for Leukocyte adhesion deficiency type-1associated cases.This report contributes to the scarce literature on acute mastoiditis in LAD-1 and underscores the need for a tailored,multidisciplinary approach.In the absence of standardized treatment protocols,further research is crucial to refine management strategies and improve outcomes in immunocompromised patients with acute otitis media complications.

关 键 词：Leukocyte Adhesion Defect IMMUNODEFICIENCY Acute Mastoiditis MASTOIDECTOMY 

分 类 号：R764.2[医药卫生—耳鼻咽喉科]