炎症蛋白与早发性卵巢功能不全的关联:一项双样本孟德尔随机化研究  

The association between inflammatory proteins and premature ovarian insufficiency:a two-sample Mendelian randomization study

作　　者：罗铮 杜桥 张彩荣[1] LUO Zheng;DU Qiao;ZHANG Cairong(Acupuncture and Moxibustion Department of Nanjing Hospital of Traditional Chinese Medicine,Nanjing 210001,Jiangsu)

机构地区：[1]南京中医药大学附属南京市中医院针灸科,210001

出　　处：《中国生育健康杂志》2025年第3期214-219,共6页Chinese Journal of Reproductive Health

基　　金：江苏省社会发展基金(BE2020624);冀来喜全国名中医传承工作室。

摘　　要：目的应用孟德尔随机化方法探讨循环炎症蛋白与早发性卵巢功能不全(POI)的因果关系。方法基于全基因关联研究(GWAS)汇总数据进行分析,以炎症蛋白作为暴露因素,选择与炎症蛋白相关的单核苷酸多态性(SNPs)作为工具变量,POI作为结局因素。运用IVW、MR-Egger法、Simple Mode法、Weighted median法和Weighted Mode法进行分析,对结果进行敏感性评估。结果胶质细胞源性神经营养因子(OR=1.558,95%CI:1.078~2.252)、白血病抑制因子(OR=1.580,95%CI:1.027~2.429)与POI的发生呈正相关,白介素10(OR=0.653,95%CI:0.462~0.922)与POI的发生呈负相关,敏感性评估显示结果均不存在水平多效性、异质性。结论胶质细胞源性神经营养因子、白血病抑制因子是POI发生的危险因素,白介素10是POI发生的保护因素。Objective To explore the causal relationship between circulating inflammatory proteins and premature ovarian insufficiency(POI)using Mendelian randomization method.Methods Based on the data collected from the genome-wide association studies(GWAS),inflammatory proteins were used as exposure factors,single nucleotide polymorphisms(SNPs)associated with inflammatory proteins were selected as instrumental variables,and POI was used as the outcome factor.We used IVW,MR Egger,simple mode,weighted media,and weighted mode methods to analyze and evaluate the sensitivity of the results.Results Glial cell-derived neurotrophic factor(OR=1.558,95%CI:1.078-22.52),leukemia inhibitory factor(OR=1.580,95%CI:1.027-2.429)showed a positive correlation with the occurrence of POI,while interleukin-10(OR=0.653,95%CI:0.462-0.922 showed a negative correlation with the occurrence of POI.Sensitivity assessment showed no horizontal pleiotropy,heterogeneity,or reverse causality.Conclusion Glial cell-derived neurotrophic factor and leukemia inhibitory factor are risk factors for POI,while interleukin-10 is a protective factor for POI occurrence.

关 键 词：炎症蛋白 早发性卵巢功能不全 孟德尔随机化 

分 类 号：R71[医药卫生—妇产科学]