清肺止痉活血法联合西医疗法治疗小儿支原体肺炎痰热闭肺证的临床研究  

Clinical study on antispasc and blood circulation combined with western medicine therapy of mycoplasma pneumonia in children

作　　者：耿宁 陈功福 GENG Ning;CHEN Gongfu(Xinyang People's Hospital,Xinyang 464000,China)

机构地区：[1]信阳市人民医院,河南信阳464000

出　　处：《四川中医》2025年第3期159-162,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:探讨清肺止痉活血法联合西医疗法治疗小儿支原体肺炎痰热闭肺证的临床疗效。方法:选取2022年1月~2023年本院收治的小儿支原体肺炎痰热闭肺证患者122例作为研究对象,按随机数字表法将其分成对照组(n=61)和实验组(n=61),前者单纯予以西医疗法(阿奇霉素)治疗,后者予以阿奇霉素联合清肺止痉活血法治疗,比较两组治疗前后白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)等炎性因子表达,达峰时间(TPTEF)、用力呼气峰流速(PEF)等肺功能指标、呼吸指标及不良反应发生率。结果:(1)实验组治疗前IL-6、TNF-α表达与对照组相比差异不显著(P>0.05),治疗后两组IL-6、TNF-α表达均下降,实验组下降程度较对照组更明显(P<0.05)。(2)实验组治疗前TPTEF、PEF与对照组相比差异不显著(P>0.05),治疗后两组TPTEF、PEF均显著升高,实验组TPTEF升高程度较对照组更显著(P<0.05),PEF升高程度较对照组更显著,但差异不显著(P>0.05)。(3)对照组总不良反应发生率21.31%,实验组6.56%,组间相比实验组的不良反应发生率较对照组更低(P<0.05)。结论:清肺止痉活血法联合西医疗法(阿奇霉素)治疗小儿支原体肺炎痰热闭肺证的临床疗效显著,对抑制炎性反应,改善肺功能有益,不良反应发生率低。Objective: To investigate the clinical effect of treating phlegm fever with mycoplasma pneumonia. Methods: 122 patients with mycoplasma pneumonia from January 2022 to 2023 were selected,it was divided into control group ( n =61) and experimental group ( n =61),the former was treated with western medicine (azithromycin),the latter was treated with azithromycin combined with pulmonary spasmodic clearing and blood circulation,comparing pre-and post-treatment interleukin-6(IL-6),tumor necrosis factor-α (TNF-α) and other inflammatory factors are expressed,peak up time (TPTEF),forced peak expiratory flow velocity (PEF) and other pulmonary function indicators,respiratory indicators and the incidence of adverse reactions. Results: ①The expression of IL-6and TNF-α in the experimental group before treatment was not significantly different from that in the control group ( P >0.05). After treatment,the expression of IL-6and TNF-α in both groups decreased,and the decrease in the experimental group was more significant than that in the control group ( P <0.05). ②The expression of TPTEF and PEF in the experimental group before treatment was not significantly different from that in the control group ( P >0.05). After treatment,the expression of TPTEF and PEF in both groups increased significantly,and the increase in the experimental group was more significant than that in the control group ( P <0.05). The increase in PEF was more significant than that in the control group,but the difference was not significant ( P >0.05). ③The total incidence of adverse reactions in the control group was 21.31%,and that in the experimental group was 6.56%. Compared with the control group,the incidence of adverse reactions in the experimental group was lower than that in the control group ( P <0.05). Conclusion: The clinical effect of Qingfeizhijing Huoxue method combined with western medicine (azithromycin) in the treatment of children with mycoplasma pneumonia with phlegm-heat syndrome of lung blockage is significant,which is benefici

关 键 词：清肺止痉活血法 阿奇霉素 西医疗法 小儿支原体肺炎 痰热闭肺证 

分 类 号：R256.1[医药卫生—中医内科学]