半胱胺修饰铜配合物荧光法检测阿莫西林  

Cysteamine modified copper complex for the fluorescence detection of amoxicillin

作　　者：史博文 唐晓丹[1] 于洪梅[1] SHI Bowen;TANG Xiaodan;YU Hongmei(School of Chemical Engineering,University of Science and Technology Liaoning,Anshan 114051,China)

机构地区：[1]辽宁科技大学化学工程学院,鞍山114051

出　　处：《分析试验室》2025年第4期556-563,共8页Chinese Journal of Analysis Laboratory

基　　金：辽宁省教育厅项目(LJKMZ20220654)资助。

摘　　要：本研究制备了半胱胺修饰的铜配合物(Cu-Cy),并将其用于制备荧光探针Cu-Cy-I。荧光探针Cu-Cy-I具有较大的斯托克斯位移(242 nm)和较好的荧光稳定性,对抗生素类药物阿莫西林(AMX)表现出较高的选择性和优异的灵敏度,并基于静态猝灭和内滤效应的协同作用,实现了对阿莫西林的有效识别。在阿莫西林浓度0.5~15μmol/L范围内,检出限为0.136μmol/L。荧光探针Cu-Cy-I成功用于市售胶囊中阿莫西林含量的测定,加标回收率为98.2%~101.6%。Cysteamine modified copper complex(Cu-Cy)was prepared and used to construct fluorescence probe Cu-Cy-I,which has a large Stokes shift(242 nm)and good fluorescence stability and shows high selectivity and excellent sensitivity to the antibiotic drug amoxicillin(AMX).Based on the synergistic effect of static quenching and internal filtration effects,the effective recognition of amoxicillin was achieved in the range of 0.5-15μmol/L with a detection limit of 0.136μmol/L.The fluorescence probe Cu-Cy-I has been successfully used for the determination of amoxicillin in commercial capsules with the recoveries of 98.2%-101.6%.

关 键 词：半胱胺修饰铜配合物 荧光探针 阿莫西林 猝灭机理 

分 类 号：O657.3[理学—分析化学]