功能材料在抗生素分离分析中的应用  

Application of functional materials in separation and analysis of antibiotics

作　　者：吴文璞 李晓维 魏国 隋磊 许卉[1] 宋志花 WU Wenpu;LI Xiaowei;WEI Guo;SUI Lei;XU Hui;SONG Zhihua(School of Pharmacy,Yantai University,Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong,Key Laboratory of Molecular Pharmacology and Drug Evaluntion,Ministry of Eduction,Yantai 264005,China)

机构地区：[1]烟台大学药学院,新型制剂与生物技术药物研究山东省高校协同创新中心,分子药理和药物评价教育部重点实验室,烟台264005

出　　处：《分析试验室》2025年第4期609-616,共8页Chinese Journal of Analysis Laboratory

基　　金：山东省自然科学基金青年基金项目(ZR2023QB268);药学国家级实验教学示范中心(烟台大学)项目资助。

摘　　要：抗生素在医药与农业领域发挥了重要作用,有效抑制了细菌感染性疾病,但抗生素的滥用正威胁人类的生活健康与生态系统的正常运行。鉴于此,抗生素类化合物的分离分析具有重要意义。分离抗生素的技术主要有样品前处理、传感分析、色谱分离等;应用的材料主要包括分子印迹聚合物、金属有机框架材料、碳材料等。此类功能材料具有优异的物理化学性质,能够实现抗生素类药物的高效分离和分析。本文对分离抗生素的几种新型功能材料进行了汇总,分析了其特点,并对目前存在的问题及日后的研究方向进行了总结与展望。Antibiotics play an important role in medicine and agriculture and can effectively inhibit bacterial infectious diseases.But the abuse of antibiotics is threatening our health and the ecosystem.Therefore,the separation and analysis of antibiotic compounds is significant.The main technologies for the analysis of antibiotics include sample pretreatment,sensor analysis,and chromatographic separation.The materials mainly comprise molecularly imprinted polymers,metal-organic framework,and carbon materials.The functional materials own excellent physical and chemical properties,which can realize efficient separation and analysis of antibiotic drugs.Several new functional materials for separation of antibiotics are summarized,their characteristics are analyzed,and the existing problems and future research directions are outlined and prospected.

关 键 词：抗生素 分离 金属有机框架 分子印迹聚合物 碳材料 离子液体 

分 类 号：R917[医药卫生—药物分析学]