基因编辑猪的应用进展  

Advances in the Application of Gene-edited Pigs

作　　者：段晓翠 白文娟[3] 史潇靖 周荣[2] 王子帅 DUAN Xiaocui;BAI Wenjuan;SHI Xiaojing;ZHOU Rong;WANG Zishuai(Henan Agricultural University,Zhengzhou 450046,China;Institute of Animal Sciences of Chinese Academy of Agricultural Sciences,Beijing 100193,China;National Animal Husbandry Services,Beijing 100125,China;Agricultural Genomics Institute at Shenzhen,Chi-nese Academy of Agricultural Sciences,Shenzhen 518124,China)

机构地区：[1]河南农业大学,河南郑州450046 [2]中国农业科学院北京畜牧兽医研究所,北京100193 [3]全国畜牧总站,北京100125 [4]中国农业科学院(深圳)农业基因组研究所,广东深圳518124

出　　处：《中国猪业》2025年第2期23-34,共12页China Swine Industry

基　　金：国家自然科学基金(32472855;32441082)。

摘　　要：基因编辑技术能够精确靶向修饰生物体基因组特定位点,在农业生物的遗传改良和生物医学研究领域得到了广泛应用,特别是在猪的基因编辑技术和新材料创制工作中取得了显著进展。本文旨在讨论基因编辑猪的技术和应用进展,探讨其在农业生产、生物医学研究和伦理监管方面的现状与挑战,以期为猪遗传改良和医学研究提供参考。Gene editing technology has been demonstrated to have the capacity to target and modify specific locus in the genome of organisms with a high degree of precision.Its utilization in the genetic enhancement of agricultural organisms and biomedical research has been extensive,particularly in the domain of gene editing technology in pigs and the creation of new materials,a field which has undergone a remarkable development.The aim of this paper was to discuss the technological and application progress of gene-edited pigs,and to explore the current situation and challenges in agricultural production,biomedical research and ethical regulation,with a view to providing reference for pig genetic improvement and medical research.

关 键 词：猪 养猪业 基因编辑 基因修饰 遗传改良 农业生产 医学研究 新材料 

分 类 号：S828[农业科学—畜牧学] S814.8[农业科学—畜牧兽医]