嗜酸性粒细胞源性神经毒素在过敏性疾病中的应用进展  

Advances in the application of eosinophil-derived neurotoxin in allergic diseases

作　　者：夏荷婷 代妮妮 李在玲[1] Xia Heting;Dai Nini;Li Zailing(Department of Pediatrics,Peking University Third Hospital,Beijing 100191,China)

机构地区：[1]北京大学第三医院儿科,100191

出　　处：《国际儿科学杂志》2025年第3期151-154,共4页International Journal of Pediatrics

基　　金：国家重点研发计划(2023YFC2706503)。

摘　　要：嗜酸性粒细胞源性神经毒素(eosinophil-derived neurotoxin,EDN)是一种在嗜酸性粒细胞活化时释放的胞内蛋白,具有核糖核酸酶活性,作为关键的免疫调节分子,对机体的免疫应答具有重要影响。作为生物标志物,EDN能够反映嗜酸性粒细胞的活动状态,为过敏性疾病的诊断与动态监测提供了有力支持。该文重点探讨了EDN在多种过敏性疾病中的应用,包括其作为诊断工具的有效性、评估病情严重程度及预后情况。通过综述现有研究成果,旨在为相关领域的进一步研究和临床实践提供参考。Eosinophil-derived neurotoxin(EDN)is an intracellular protein released during eosinophil activation,possessing ribonuclease activity.As a pivotal immunoregulatory molecule,EDN exerts significant influence on the immune response of the organism.Serving as a biomarker,it can reflect the activation state of eosinophils,providing robust support for the diagnosis and dynamic monitoring of allergic diseases.This article focuses on the application of EDN in various allergic diseases,including its effectiveness as a diagnostic tool,assessment of disease severity,and prognosis.By reviewing existing research findings,this review aims to provide references for further research and clinical practice in related fields.

关 键 词：嗜酸性粒细胞源性神经毒素 过敏性疾病 生物标志物 

分 类 号：R593.1[医药卫生—内科学]