胆汁酸与艰难梭菌感染研究进展  

Progress on bile acids and Clostridioides difficile infection

作　　者：涂乐文 李小露[1] 王怡仲 张婷[1] Tu Lewen;Li Xiaolu;Wang Yizhong;Zhang Ting(Department of Gastroenterology,Hepatology and Nutrition,Shanghai Children's Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200062,China)

机构地区：[1]上海市儿童医院,上海交通大学医学院附属儿童医院消化科,200062

出　　处：《国际儿科学杂志》2025年第3期155-159,共5页International Journal of Pediatrics

基　　金：国家自然科学基金(82470572)。

摘　　要：艰难梭菌感染(Clostridioides difficile infection,CDI)是抗生素相关性腹泻的常见原因,给全球卫生医疗保健系统带来了巨大的负担。艰难梭菌通过芽孢在体外进行传播,在体内肠道萌发生长形成营养细胞,释放毒素从而致病。胆汁酸是肠道重要代谢物,初级胆汁酸和次级胆汁酸在艰难梭菌生命周期中发挥重要作用。该文就胆汁酸代谢、胆汁酸代谢影响CDI的相关机制以及通过抗菌药和粪菌移植(fecal microbiota transplantation,FMT)进行CDI治疗时对胆汁酸的影响进行综述,以期对CDI的临床治疗和研究带来新的依据和参考。Clostridioides difficile infection(CDI)is a common cause of antibiotic-associated diarrhea,posing a significant burden on global healthcare systems.Clostridioides difficile(C.difficile)spreads through spores outside the body,germinates and grows into vegetative cells in the intestines,and releases toxins to cause disease.Bile acids are crucial metabolites in the gut,where primary and secondary bile acids play important roles throughout the lifecycle of C.difficile.This article reviews bile acids metabolism,their impact on C.difficile,and how they influence CDI treatment through antibiotics and fecal microbiota transplantation(FMT).The aim is to provide new insights and reference for clinical management and research of CDI.

关 键 词：胆汁酸 艰难梭菌感染 抗生素 粪菌移植 

分 类 号：R378[医药卫生—病原生物学]