FGF23与慢性肾脏病5期透析患者贫血相关性研究  

Study on the Relationship Between FGF23 and Anemia in Patients with Chronic Kidney Disease on Stage 5 Dialysis

作　　者：李黎 张曦[1] 李俊[2] 潘思敏 Li Li;Zhang Xi;Li Jun(Department of Nephrology,Kunming First People’s Hospital,Kunming,Yunnan,650200,China)

机构地区：[1]昆明市第一人民医院肾内科,云南昆明650200 [2]昆明医科大学第一附属医院肾内科,云南昆明650032

出　　处：《黑龙江医学》2025年第8期899-901,共3页Heilongjiang Medical Journal

基　　金：云南省教育厅科学研究基金资助项目(2022J0269);云南省昆明市卫生健康委员会卫生科研课题项目(2022-03-05-003);云南省昆明市卫生科技人才培养项目[2022-SW(后备)-86];云南省高层次人才培养支持计划基金资助项目(RLMY20200022);国家级教学质量工程基金资助项目(2022JXD209)。

摘　　要：目的:探讨成纤维细胞生长因子23(FGF23)、Klotho蛋白与慢性肾脏病(CKD)5期透析患者贫血的相关性。方法:选取2022年5月—2023年2月样本医院收治的80例CKD 5期透析患者作为研究对象,随机将其分为观察组与对照组,每组各40例。比较两组患者血清白蛋白(ALB)、血清铁蛋白(FER)、甲状旁腺激素(PTH)、血清总钙离子(Ca^(2+))、血清磷(P)、Klotho蛋白、FGF23蛋白水平。观察FGF23、Klotho蛋白与ALB、FER、PTH、Ca^(2+)、P的相关性。结果:观察组患者ALB、Ca^(2+)水平高于对照组,PTH、P水平低于对照组,差异均有统计学意义(t=0.502,P<0.05;U=-3.998、-4.171、-2.789,P<0.05)。观察组患者FGF23水平高于对照组,Klotho蛋白水平低于对照组,差异均有统计学意义(t=10.453、18.286,P<0.05)。FGF23与P呈正相关(r=0.568),与ALB、PTH均呈负相关(r=-0.096、-0.288);Klotho蛋白与ALB、PTH均呈正相关(r=0.146、0.182),与P呈负相关(r=0.415),差异均有统计学意义(P<0.05);Klotho蛋白、FCF23及Klotho蛋白-FCF23联合检测CKD 5期透析患者贫血的受试者工作特征(ROC)曲线下面积(AUC)分别为0.869、0.857、0.881,特异度分别为82.7%、81.6%、81.5%,灵敏度分别为87.8%、91.9%、92.2%。结论:Klotho蛋白、FCF23与CKD5期透析患者ALB、PTH、Ca^(2+)、P存在相关性,Klotho蛋白及FGF23预测CKD 5期透析患者贫血的价值较高,可作为监测指标。Objective:To investigate the relationship between Fibroblast growth factor 23(FGF23),klotho protein and anemia in Chronic kidney disease stage 5(CKD5)dialysis patients.Methods:40 CKD5 stage anemia patients who underwent dialysis in the hospital from May 2022 to February 2023 were selected as the observation group,and 40 CKD5 stage non anemia patients who underwent dialysis during the same period were selected as the control group.Serum albumin(ALB),serum Ferritin(FER),parathyroid hormone(PTH),total calcium ion(Ca^(2+)),serum phosphorus(P),Klotho,FGF23 protein levels were compared between the two groups.The correlation between FGF23,Klotho and ALB,FER,PTH,Ca2+and P were observed.Results:The levels of ALB and Ca^(2+)in observation group were higher than those in control group,while the levels of PTH and P in observation group were lower than those in control group,with statistical significance(t=0.502,P<0.05;U=-3.998,-4.171,-2.789;P<0.05).The FGF23 level in observation group was higher than that in control group,and the Klotho protein level in observation group was lower than that in control group,with statistically significant difference(t=10.453,18.286;P<0.05).FGF23 was positively correlated with P(r=0.568),and negatively correlated with ALB and PTH(r=-0.096,-0.288).Klotho protein was positively correlated with ALB and PTH(r=0.146,0.182),and negatively correlated with P(r=0.415),and the differences were statistically significant(P<0.05).The area under ROC curve(AUC)of Klotho protein,FCF23 and Klotho protein-FCF23 were 0.869,0.857 and 0.881,respectively.The specificity was 82.7%,81.6%and 81.5%.And the sensitivity was 87.8%,91.9%and 92.2%,respectively.Conclusion:There is correlation between Klotho,FCF23 and ALB,PTH,Ca^(2+),P in CKD5 dialysis anemia patients.Klotho protein and FGF23 protein have high predictive value for CKD5 dialysis anemia and can be used as monitoring indicators.

关 键 词：慢性肾脏病 透析 成纤维细胞生长因子23 KLOTHO蛋白 相关性 

分 类 号：R47[医药卫生—护理学]