喹硫平联合认知行为疗法对精神分裂症患者 负性 情绪、药物依从性的影响研究  

Effects of Quetiapine Combined with Cognitive Behavioral Therapy on Negative Emotions and Medication Compliance in Patients with Schizophrenia

作　　者：鲁满云 胡孝芬 韩友松 杨映丹 LU Manyun;HU Xiaofen;HAN Yousong;YANG Yingdan(Dept.of Clinical Psychology,Anqing Sixth People’s Hospital,Anhui Anqing 246000,China)

机构地区：[1]安庆市第六人民医院临床心理科,安徽安庆246000

出　　处：《中国医院用药评价与分析》2025年第4期438-441,共4页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨喹硫平联合认知行为疗法对精神分裂症患者负性情绪、药物依从性的影响。方法:选取2022年7月至2023年10月于该院临床心理科接受治疗的精神分裂症患者110例进行回顾性研究,依据病历系统记录的不同治疗方式分为对照组(n=53,喹硫平)、观察组(n=57,喹硫平联合认知行为疗法),对比两组患者的状态-特质焦虑问卷(STAI)、药物依从性量表(MAS)、阳性和阴性症状量表(PANSS)及精神分裂症患者生活质量量表(SQLS)评分。结果:治疗前,两组患者STAI、MAS、PANSS和SQLS评分的差异均无统计学意义(P>0.05);治疗后,观察组患者的STAI、PANSS和SQLS评分低于对照组,MAS评分高于对照组,差异均有统计学意义(P<0.05)。结论:喹硫平联合认知行为疗法能够在一定程度上改善患者的临床症状,缓解焦虑情绪,提高药物依从性及生活质量。OBJECTIVE:To probe into the effects of quetiapine combined with cognitive behavioral therapy on negative emotions and medication compliance in patients with schizophrenia.METHODS:A total of 110 patients with schizophrenia who were treated in the Clinical Psychology Department of the hospital from Jul.2022 to Oct.2023 were selected for a retrospective study,which were divided into control group(53 cases,received quetiapine)and observation group(57 cases,received quetiapine combined with cognitive behavioral therapy)according to different treatment methods recorded in the medical record system,both groups were compared in terms of the State-Trait Anxiety Inventory(STAI),Medication Adherence Scale(MAS),Positive and Negative Symptom Scale(PANSS)and Schizophrenic Quality of Life Scale(SQLS)scores.RESULTS:Before treatment,there were no statistically significant differences in STAI,MAS,PANSS and SQLS scores between two groups(P>0.05).After treatment,the STAI,PANSS and SQLS scores of observation group were lower than those of the control group,and the MAS score was higher than that of the control group,with statistically significant differences(P<0.05).CONCLUSIONS:Quetiapine combined with cognitive-behavioral therapy can improve the clinical symptoms,alleviate anxiety,improve drug compliance and quality of life for patients to a certain extent.

关 键 词：精神分裂症 喹硫平 认知行为疗法 负性情绪 药物依从性 

分 类 号：R971[医药卫生—药品]