2169张门诊雷公藤制剂处方用药分析及药学监护策略  

Drug Use Analysis and Pharmaceutical Care Strategies for 2169 Outpatient Prescriptions of Tripterygium Wilfordii Preparations

作　　者：周燊 宋新 侯新[1] 陈雯[1] 金敏 ZHOU Shen;SONG Xin;HOU Xin;CHEN Wen;JIN Min(Dept.of Pharmacy,Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Dept.of Pharmacy,Peking University Third Hospital,Beijing 100191,China)

机构地区：[1]中国中医科学院广安门医院药学部,北京100053 [2]北京大学第三医院药学部,北京100191

出　　处：《中国医院用药评价与分析》2025年第4期474-478,483,共6页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：北京药学会临床药学研究项目(No.LCYX-2024-12);白求恩公益基金会“2022白求恩·求索-药学科研能力建设”项目;中国中医科学院中药监管科学研究项目(No.中科科便函〔2024〕25号)。

摘　　要：目的:以雷公藤多苷片为例,探讨雷公藤制剂用药的合理性及药学监护策略,为临床合理应用雷公藤制剂及其他高风险中成药提供参考。方法:通过医院信息系统,收集2023年3-12月中国中医科学院广安门医院(以下简称“该院”)雷公藤多苷片门诊处方信息并进行统计分析,以此为依据探讨雷公藤制剂临床用药监护策略。结果:2023年3-12月该院雷公藤多苷片门诊处方数合计2169张,患者年龄为20~93岁;其中,男性患者660例,女性患者1509例;患者主要来自风湿免疫科(1602例,占73.86%)、皮肤科(266例,占12.26%)和肾病门诊(178例,占8.21%)等。该院雷公藤多苷片存在高用药风险,监护要点为特殊人群用药、超剂量用药、超疗程用药和超适应证用药;其中,超适应证用药处方占总处方数的38.54%(836张)。结论:雷公藤多苷片及其他雷公藤制剂临床应用广泛,患者年龄分布较广,临床使用应建立相应的药学监护策略,加强用药监测,减少药品不良反应的发生,促进雷公藤制剂的合理应用,为其他高风险药品的药学监护和管理提供参考。OBJECTIVE:Taking Tripterygium wilfordii glycosides tablets as an example,to explore the application rationality of Tripterygium wilfordii preparations and pharmaceutical care strategies,so as to provide references for the rational application of Tripterygium wilfordii preparations and other high-risk Chinese patent medicines.METHODS:Through the hospital information system,the outpatient prescription information of Tripterygium wilfordii glycosides tablets in Guang’anmen Hospital,China Academy of Chinese Medical Sciences(hereinafter referred to as“the hospital”)from Mar.to Dec.2023 was collected and statistically analyzed.Clinical medication monitoring strategies for Tripterygium wilfordii preparations were analyzed.RESULTS:The total number of outpatient prescriptions for Tripterygium wilfordii glycosides tablets in the hospital from Mar.to Dec.2023 was 2169,with ages ranged from 20 to 93 years.Among them,660 were males and 1509 were females.The patients were mainly from the Department of Rheumatology(1602 cases,73.86%),Dermatology(266 cases,12.26%)and Nephropathy Outpatient(178 cases,8.21%).There was a high risk of drug use of Tripterygium wilfordii glycosides tablets in the hospital.The key points of monitoring were drug use for special groups,off-label dosage,off-label course of treatment and off-label indication,the number of off-label indication prescriptions was 38.54%(836 prescriptions).CONCLUSIONS:Tripterygium wilfordii glycosides tablets and other Tripterygium wilfordii preparations are widely used in clinical practice,with a wide age distribution of patients.Pharmaceutical monitoring strategies should be summarized to promote rational drug use in clinic,strengthen medication monitoring,reduce the occurrence of adverse drug reactions,promote rational use of Tripterygium wilfordii preparations,and provide reference for pharmaceutical monitoring and management of other high-risk pharmaceuticals.

关 键 词：雷公藤制剂 临床应用 药学监护 合理用药 

分 类 号：R969.3[医药卫生—药理学]